2017擭乮暯惉29擭乯

榑暥

1.	Targeted sequencing reveals genetic variants associated with sensitivity of 79 human cancer xenografts to anticancer drugs.
	Udagawa C, Sasaki Y, Suemizu H, Ohnishi Y, Ohnishi H, Tokino T, Zembutsu H.
	Exp Ther Med. 2018 Feb;15(2):1339-1359. doi: 10.3892/etm.2017.5533. Epub 2017 Nov 21.
	PMID: 29434720 [PubMed] Free PMC Article
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2.	Downregulation of miR-186 is associated with metastatic recurrence of gastrointestinal stromal tumors.
	Niinuma T, Kai M, Kitajima H, Yamamoto E, Harada T, Maruyama R, Nobuoka T, Nishida T, Kanda T, Hasegawa T, Tokino T, Sugai T, Shinomura Y, Nakase H, Suzuki H.
	Oncol Lett. 2017 Nov;14(5):5703-5710. doi: 10.3892/ol.2017.6911. Epub 2017 Sep 8.
	PMID: 29113198 [PubMed] Free PMC Article
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3.	Identification and characterization of a metastatic suppressor BRMS1L as a target gene of p53.
	Koyama R, Tamura M, Nakagaki T, Ohashi T, Idogawa M, Suzuki H, Tokino T, Sasaki Y.
	Cancer Sci. 2017 Dec;108(12):2413-2421. doi: 10.1111/cas.13420. Epub 2017 Nov 6.
	PMID: 29030916 [PubMed - indexed for MEDLINE] Free PMC Article
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4.	Profiling cancer-related gene mutations in oral squamous cell carcinoma from Japanese patients by targeted amplicon sequencing.
	Nakagaki T, Tamura M, Kobashi K, Koyama R, Fukushima H, Ohashi T, Idogawa M, Ogi K, Hiratsuka H, Tokino T, Sasaki Y.
	Oncotarget. 2017 Jul 15;8(35):59113-59122. doi: 10.18632/oncotarget.19262. eCollection 2017 Aug 29.
	PMID: 28938622 [PubMed] Free PMC Article
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5.	Fledglings in p53 signaling network.
	Tokino T, Idogawa M, Sasaki Y.
	Oncotarget. 2017 Jul 14;8(34):55768-55769. doi: 10.18632/oncotarget.19229. eCollection 2017 Aug 22. No abstract available.
	PMID: 28925413 [PubMed - in process] Free PMC Article
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6.	Assessment of the quality of DNA from various formalin-fixed paraffin-embedded (FFPE) tissues and the use of this DNA for next-generation sequencing (NGS) with no artifactual mutation.
	Einaga N, Yoshida A, Noda H, Suemitsu M, Nakayama Y, Sakurada A, Kawaji Y, Yamaguchi H, Sasaki Y, Tokino T, Esumi M.
	PLoS One. 2017 May 12;12(5):e0176280. doi: 10.1371/journal.pone.0176280. eCollection 2017.
	PMID: 28498833 [PubMed - indexed for MEDLINE] Free PMC Article
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7.	Long non-coding RNA NEAT1 is a transcriptional target of p53 and modulates p53-induced transactivation and tumor-suppressor function.
	Idogawa M, Ohashi T, Sasaki Y, Nakase H, Tokino T.
	Int J Cancer. 2017 Jun 15;140(12):2785-2791. doi: 10.1002/ijc.30689. Epub 2017 Mar 27.
	PMID: 28295289 [PubMed - indexed for MEDLINE]
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8.	p53 mediates the suppression of cancer cell invasion by inducing LIMA1/EPLIN.
	Ohashi T, Idogawa M, Sasaki Y, Tokino T.
	Cancer Lett. 2017 Apr 1;390:58-66. doi: 10.1016/j.canlet.2016.12.034. Epub 2017 Jan 13.
	PMID: 28093207 [PubMed - indexed for MEDLINE]
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9.	The effect of forced expression of mutated K-RAS gene on gastrointestinal cancer cell lines and the IGF-1R targeting therapy.
	Matsunaga Y, Adachi Y, Sasaki Y, Koide H, Motoya M, Nosho K, Takagi H, Yamamoto H, Sasaki S, Arimura Y, Tokino T, Carbone DP, Imai K, Shinomura Y.
	Mol Carcinog. 2017 Feb;56(2):515-526. doi: 10.1002/mc.22513. Epub 2016 Jun 23.
	PMID: 27312358 [PubMed - indexed for MEDLINE]
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妛夛敪昞

1. Idogawa M, Suzuki N, Ohashi T, Sasaki Y, Tokino T. The identification of p53 target genes and noncoding RNAs through the combined analysis of RNA-seq and ChIP-seq data. The 17th International p53 Workshop. Jul, 2017. Singapore.
2. Sasaki Y, Nakagaki T, Tamura M, Fukushima F, Ikeda H, Koyama R, Idogawa M, Tokino T. Targeted exome sequences of cancer-related genes in human cancers using amplicon sequencing. American Association of Cancer Research (AACR) annual meeting 2017. Apr, 2017丏Washington DC, USA.
3. Iwaya T, Endo F, Kume K, Sasaki Y, Tokino T, Nishizuka S. Mutation detection by target sequence analyses using tissue-specific panels in esophageal squamous cell carcinoma. American Association of Cancer Research (AACR) annual meeting 2017. Apr, 2017. Washington DC, USA.
4. Udagawa C, Sasaki Y, Suemizu H, Ohnishi Y, Ohnishi H, Tokino T, Zembutsu H. Exome sequencing of cancer-related genes to identify genetic markers for sensitivity to cytotoxic anticancer drugs. American Association of Cancer Research (AACR) annual meeting 2017. Apr, 2017. Washington DC, USA.
5. Fukushima H, Sasaki Y, Tamura M, Ikeda H, Ishiguro K, Tokino T, Sakurai A. Profiling cancer-related gene alterations in Japanese multiple myeloma patients by targeted amplicon sequencing. European Human Genetics Conference 2017. May, 2017. Copenhagen S, Denmark.
6. Sasaki Y, Nakagaki T, Tamura M, Kobashi K, Koyama R, Fukushima F, Idogawa M, Ogi K, Hiratsuka H, Tokino T. Profiling cancer-related gene mutations in oral squamous cell carcinoma from Japanese patients by targeted amplicon sequencing. The 12th International Workshop on Advanced Genomics. Jun, 2017. Tokyo, Japan.
7. 嵅乆栘 懽巎, 揷懞 傒備偒, 拞奯 婱暥, 彫嶳 椙懢, 堜屗愳 夒巎, 壃 榓峅, 暯捤 攷媊, 拠悾 桾巙, 帪栰 棽帄丏岥峯滸暯忋旂娻偺慡僄僋僜儞夝愅丏戞75夞擔杮娻妛夛妛弍憤夛丏 2017擭俋寧丆墶昹丏
8. 堜屗愳 夒巎, 戝敘 抭巕, 嵅乆栘 懽巎, 帪栰 棽帄丏娻偵偍偗傞p53昗揑挿嵔旕僐乕僪RNA(lncRNA)偺扵嶕偲敪尰僱僢僩儚乕僋夝愅丏戞75夞擔杮娻妛夛妛弍憤夛丏 2017擭俋寧丆墶昹丏
9. 拞奯 婱暥, 嵅乆栘 懽巎, 堜屗愳 夒巎, 彫嶳 椙懢, 揷懞 傒備偒, 暉搰 媣戙, 壃 榓峅, 暯捤 攷媊, 帪栰 棽帄丏師悽戙僔乕僋僄儞僒乕偵傛傞擔杮恖丂岥峯滸暯忋旂娻偵偍偗傞偑傫娭楢409堚揱巕偺曄堎夝愅丏戞75夞擔杮娻妛夛妛弍憤夛丏 2017擭俋寧丆墶昹丏
10. 庒悪 塸庽, 楅栘 戱, 嵅乆栘 婎, 怴徖 栆, 嶳杮 塸堦榊, 峛斻 惓峀, 崅嫶 廏柧, 埳搶 暥惗, 帪栰 棽帄, 拠悾 桾巙丏枬惈B宆娞墛偺妀巁傾僫儘僌惢嵻帯椕屻敪偑傫偵娭梌偡傞microRNA偺扵嶕丏戞75夞擔杮娻妛夛妛弍憤夛丏 2017擭俋寧丆墶昹丏
11. 杒搱 梞巙, 娵嶳 楁弿, 嶳杮 塸堦榊, 怴徖 栆, 惵栘 宧懃, 峛斻 惓峀, 帪栰 棽帄, 崱堜 峗嶰, 拠悾 桾巙, 楅栘 戱丏枬惈堓墛偍傛傃堓娻偵娭偡傞挿嵔noncoding RNA偺摨掕偲婡擻夝愅丏戞75夞擔杮娻妛夛妛弍憤夛丏 2017擭俋寧丆墶昹丏
12. 恑摗 揘嵠, 惣嶳 捈棽, 怴徖 栆, 娵嶳 楁弿, 杒搱 梞巙, 峛斻 惓峀, 帪栰 棽帄, 慍怷 捈嵠, 楅栘 戱丏銷泖偑傫偵偍偗傞僔僗僾儔僠儞懴惈偵娭梌偡傞儅僀僋儘RNA偺扵嶕丏戞75夞擔杮娻妛夛妛弍憤夛丏 2017擭俋寧丆墶昹丏
13. 娾扟 妜, 墦摗 巎棽, 嵅乆栘 懽巎, 敧廳妦 悙揟, 愮梩 忎峀, 廐嶳 桳巎, 憹揷 枩棦, 嶳揷 揘巌, 帪栰 棽帄, 惣捤 揘丏怘摴娻姵幰偵偍偗傞Circulating tumor DNA傪梡偄偨Liquid biopsy system偺奐敪丏戞75夞擔杮娻妛夛妛弍憤夛丏 2017擭俋寧丆墶昹丏
14. 怴徖 栆, 杒搱 梞巙, 嶳杮 塸堦榊, 峛斻 惓峀, 拠悾 桾巙, 帪栰 棽帄, 崱堜 峗嶰, 楅栘 戱丏
15. 徚壔娗娫幙庮釃偵偍偄偰僄僺僕僃僱僥傿僢僋偵惂屼偝傟傞挿嵔noncoding RNA偺扵嶕丏戞75夞擔杮娻妛夛妛弍憤夛丏 2017擭俋寧丆墶昹丏
16. 愇崟 堦栫, 嵅乆栘 婎, 庒悪 塸庽, 杒搱 梞巙, 怴徖 栆, 娵嶳 楁弿, 峛斻 惓峀, 抮揷 攷, 愇揷 掯晇, 嵅乆栘 懽巎, 帪栰 棽帄, 拠悾 桾巙, 楅栘 戱丏僸僗僩儞儊僠儖壔峺慺DOT1L偼懡敪惈崪悜庮偺帯椕昗揑偲側傝偆傞丏戞75夞擔杮娻妛夛妛弍憤夛丏 2017擭俋寧丆墶昹丏
17. 嶳杮 塸堦榊, 嶳栰 懽曚, 惵栘 宧懃, 怴徖 栆, 峛斻 惓峀, 嵅乆栘 懽巎, 帪栰 棽帄, 悰堜 桳, 拠悾 桾巙, 楅栘 戱丏戝挵庮釃偺昞柺峔憿偑斀塮偡傞庮釃撪晄嬒堦惈丏戞75夞擔杮娻妛夛妛弍憤夛丏 2017擭俋寧丆墶昹丏
18. 戝挵偑傫偵偍偗傞庮釃寣娗撪旂娭楢堚揱巕偺摨掕丏漭 尠, 嶳杮 塸堦榊, 徖揷 桳搇, 怴徖 栆, 杒搱 梞巙, 峛斻 惓峀, 惵栘 宧懃, 庒悪 塸庽, 帪栰 棽帄, 拞悾 桾巙, 悰堜 桳, 楅栘 戱丏戞75夞擔杮娻妛夛妛弍憤夛丏 2017擭俋寧丆墶昹丏
19. 怴婯戝挵偑傫慄堐夎嵶朎娭楢堚揱巕偺摨掕丏徖揷 桳搇, 漭 尠, 嶳杮 塸堦榊, 怴徖 栆, 杒搱 梞巙, 峛斻 惓峀, 惵栘 宧懃, 庒悪 塸庽, 帪栰 棽帄, 拠悾 桾巙, 悰堜 桳, 楅栘 戱丏戝挵偑傫偵偍偗傞庮釃寣娗撪旂娭楢堚揱巕偺摨掕丏戞75夞擔杮娻妛夛妛弍憤夛丏 2017擭俋寧丆墶昹丏
20. 岥峯滸暯忋旂娻偵娭梌偡傞挿嵔旕僐乕僪RNA偺摨掕丏惣嶳 淎梲, 娵嶳 楁弿, 怴徖 栆, 杒搱 梞巙, 壃 榓峅, 弌挘 桾栫, 媨嶈 峎榡, 峛斻 惓峀, 嵅乆栘 懽巎, 帪栰 棽帄, 暯捤 攷媊, 楅栘 戱丏戝挵偑傫偵偍偗傞庮釃寣娗撪旂娭楢堚揱巕偺摨掕丏戞75夞擔杮娻妛夛妛弍憤夛丏 2017擭俋寧丆墶昹丏
21. 嵅乆栘懽巎丆彫嶳椙懢丆揷懞傒備偒丆拞奯婱暥丆戝敘抭巕丆堜屗愳夒巎丆楅栘戱丆帪栰棽帄丏p53昗揑堚揱巕BRMS1L偺摨掕偲婡擻夝愅丏惗柦壢妛宯妛夛崌摨擭師戝夛乮ConBio2017乯丏2017擭12寧丆恄屗丏
22. 楅栘 嵷揈丆堜屗愳 夒巎丆戝敘 抭巕丆嵅乆栘 懽巎丆帪栰 棽帄丏怴婯p53昗揑偱偁傞抈敀僐乕僪堚揱巕LIMA1偲挿嵔旕僐乕僪RNA乮lncRNA乯NEAT1偺p53婡擻偵偍偗傞栶妱丏惗柦壢妛宯妛夛崌摨擭師戝夛乮ConBio2017乯丏2017擭12寧丆恄屗丏

尋媶彆惉

1. 帪栰棽帄丏p53僱僢僩儚乕僋偺棟夝偲暘巕昗揑岓曗偺扵嶕丂暯惉28-30擭搙暥晹壢妛徣壢妛尋媶旓曗彆嬥乮婎斦尋媶俠乯尋媶戙昞丏
2. 帪栰棽帄丆嵅乆栘懽巎丆堜屗愳夒巎丏乽愭恑僎僲儉夝愅尋媶悇恑僾儔僢僩僼僅乕儉乿丂暯惉28-33擭搙暥晹壢妛徣壢妛尋媶旓曗彆嬥乮怴妛弍椞堟尋媶乯尋媶巟墖暘扴丏
3. 帪栰棽帄丏暯惉29擭搙嶥杫堛壢戝妛摿掕堛妛尋媶悇恑帠嬈愭抂揑尋媶丏
4. 嵅乆栘懽巎丏怘摴滸暯忋旂娻偺敪惗丒恑揥夁掱偵偍偗傞p53僼傽儈儕乕偺栶妱偺夝柧偲怴婯帯椕愴棯丏暯惉29-31擭搙暥晹壢妛徣壢妛尋媶旓曗彆嬥乮婎斦尋媶C乯丏
5. 嵅乆栘懽巎丏乽偑傫偺屄惈乿傪昡壙偡傞堚揱巕夝愅僷僱儖偺奐敪丏岞塿怣戸丂彫栰偑傫尋媶彆惉婎嬥丂暯惉29擭搙尋媶彆惉嬥丏
6. 堜屗愳夒巎丏娻娭楢揮幨場巕偺昗揑旕僐乕僪RNA夝愅偵傛傞徚壔婍娻昦懺偺夝柧丏暯惉28-30擭搙暥晹壢妛徣壢妛尋媶旓曗彆嬥乮婎斦尋媶C乯尋媶戙昞丏
7. 堜屗愳夒巎丆嵅乆栘懽巎丆帪栰棽帄丆媨栰屽丏暯惉29擭搙搶嫗戝妛堛壢妛尋媶強嫟摨尋媶丏