2016擭乮暯惉28擭乯

榑暥

1.	p53 mediates the suppression of cancer cell invasion by inducing LIMA1/EPLIN.
	Ohashi T, Idogawa M, Sasaki Y, Tokino T.
	Cancer Lett. 2017 Jan 13;390:58-66. doi: 10.1016/j.canlet.2016.12.034. [Epub ahead of print]
	PMID: 28093207 [PubMed - as supplied by publisher]
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2.	TET1 Depletion Induces Aberrant CpG Methylation in Colorectal Cancer Cells.
	Kai M, Niinuma T, Kitajima H, Yamamoto E, Harada T, Aoki H, Maruyama R, Toyota M, Sasaki Y, Sugai T, Tokino T, Nakase H, Suzuki H.
	PLoS One. 2016 Dec 15;11(12):e0168281. doi: 10.1371/journal.pone.0168281.
	PMID: 27977763 [PubMed - in process] Free PMC Article
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3.	Identification and characterization of the intercellular adhesion molecule-2 gene as a novel p53 target.
	Sasaki Y, Tamura M, Takeda K, Ogi K, Nakagaki T, Koyama R, Idogawa M, Hiratsuka H, Tokino T.
	Oncotarget. 2016 Sep 20;7(38):61426-61437. doi: 10.18632/oncotarget.11366.
	PMID: 27556181 [PubMed - in process] Free Article
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4.	Plasticity of lung cancer stem-like cells is regulated by the transcription factor HOXA5 that is induced by oxidative stress.
	Saijo H, Hirohashi Y, Torigoe T, Horibe R, Takaya A, Murai A, Kubo T, Kajiwara T, Tanaka T, Shionoya Y, Yamamoto E, Maruyama R, Nakatsugawa M, Kanaseki T, Tsukahara T, Tamura Y, Sasaki Y, Tokino T, Suzuki H, Kondo T, Takahashi H, Sato N.
	Oncotarget. 2016 Aug 2;7(31):50043-50056. doi: 10.18632/oncotarget.10571.
	PMID: 27418136 [PubMed - in process] Free PMC Article
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5.	The effect of forced expression of mutated K-RAS gene on gastrointestinal cancer cell lines and the IGF-1R targeting therapy.
	Matsunaga Y, Adachi Y, Sasaki Y, Koide H, Motoya M, Nosho K, Takagi H, Yamamoto H, Sasaki S, Arimura Y, Tokino T, Carbone DP, Imai K, Shinomura Y.
	Mol Carcinog. 2017 Feb;56(2):515-526. doi: 10.1002/mc.22513.
	PMID: 27312358 [PubMed - in process]
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6.	A genomic screen for long noncoding RNA genes epigenetically silenced by aberrant DNA methylation in colorectal cancer.
	Kumegawa K, Maruyama R, Yamamoto E, Ashida M, Kitajima H, Tsuyada A, Niinuma T, Kai M, Yamano HO, Sugai T, Tokino T, Shinomura Y, Imai K, Suzuki H.
	Sci Rep. 2016 May 24;6:26699. doi: 10.1038/srep26699.
	PMID: 27215978 [PubMed - in process] Free PMC Article
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7.	Genomic characterization of esophageal squamous cell carcinoma: Insights from next-generation sequencing.
	Sasaki Y, Tamura M, Koyama R, Nakagaki T, Adachi Y, Tokino T.
	World J Gastroenterol. 2016 Feb 21;22(7):2284-93. doi: 10.3748/wjg.v22.i7.2284. Review.
	PMID: 26900290 [PubMed - indexed for MEDLINE] Free PMC Article
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妛夛敪昞

1. Tokino T, Tamura M, Idogawa M, Sasaki Y. p53 regulates cancer cell migration and invasion through FOXF1. Tenth AACR-JCA Joint Conference on Breakthroughs in Cancer Research: From Biology To Therapeutics. February 16, 2016, Maui, Hawaii, USA.
2. Tamura M, Sasaki Y, Kobashi K, Takeda K, Nakagaki T, Idogawa M, Tokino T. CRKL oncogene is downregulated by p53 through miR-200s. Tenth AACR-JCA Joint Conference on Breakthroughs in Cancer Research: From Biology To Therapeutics. February 16, 2016, Maui, Hawaii, USA.
3. Ohashi T,Idogawa M,Tamura M,Sasaki Y, Tokino T. AKR1B10, a transcriptional target of p53, is downregulated in colorectalcancers associated with poor prognosis. February 16, 2016, Maui, Hawaii, USA.
4. Tokino T, Tamura M, Idogawa M, Sasaki Y. p53 downregulates CRKL oncogene through miR-200. American Association of Cancer Research (AACR) annual meeting. April 19, 2016, New Orleans, USA.
5. Sasaki Y, Koyama R, Nakagaki T, Tamura M, Idogawa M, Tokino T. Targeted sequencing of 409 cancer-related genes for somatic mutations and copy number variations in human cancer using the semiconductor sequencers. American Association of Cancer Research (AACR) annual meeting. April 19, 2016, New Orleans, USA.
6. Idogawa M, Ohashi T, Sasaki Y, Tokino T. The identification of p53 target genes and noncoding RNAs through the combined analysis of RNA-seq and ChIP-seq data. American Association of Cancer Research (AACR) annual meeting. April 18, 2016, New Orleans, USA.
7. Nakagaki T, Sasaki Y, Idogawa M, Koyama R, Kobashi K, Tamura M, Ohashi T, Ogi K, Hiratsuka H, Tokino. T. Semiconductor-based next-generation sequencing analysis of 409 cancer-related genes for mutations and copy-number variations in oral squamous cell carcinoma. American Association of Cancer Research (AACR) annual meeting. April 19, 2016, New Orleans, USA.
8. Ikeda H, Sasaki Y, Ishiguro K, Ishida T, Aoki Y, Tokino T. Targeted semiconductor sequencing of 409 cancer-related genes for somatic mutations and copy number variations in multiple myeloma. American Association of Cancer Research (AACR) annual meeting. April 19, 2016, New Orleans, USA.
9. Sasaki Y, Koyama R, Nakagaki T, Tamura M, Fukushima H, Ikeda H, Koyama R, Ohashi T, Idogawa M, Tokino T. Targeted exome sequencing of cancer-related genes for somatic mutations and copy number variations in human cancer using the semiconductor sequencer 43th ISOBM Annual Congress of International Society of Oncology and BioMarkers (ISOBM). September 4, 2016, Chicago, USA.
10. Fukushima H, Ikeda H, Ishiguro K, Igarashi T, Aoki Y, Hayashi T, Ishida T, Sasaki Y, Sakurai A, Tokino T. Targeted semiconductor sequencing of 409 cancer-related genes for somatic mutations and copy number variations in multiple myeloma. The 13th Annual Meeting of the International Congress of Human Genetics, April 5, 2016, Kyoto Japan.
11. Fukushima H, Sasaki Y, Tamura M, Ikeda H, Ishiguro K, Tokino T, Sakurai A. Identification of somatic mutations and copy number variations in multiple myeloma using next generation sequencing. The 66th Annual Meeting of The American Society of Human Genetics, October 19, 2016, Vancouver, Canada.
12. 帪栰棽帄丏戞15夞擔杮晈恖壢偑傫暘巕昗揑尋媶夛 摿暿島墘 乽敪偑傫偵偍偗傞p53宱楬偺栶妱偲帯椕傊偺墳梡乿丂2016擭8寧19擔丆嶥杫丏
13. 帪栰棽帄丏乽p53宱楬偲敪偑傫乿戞75夞擔杮娻妛夛妛弍憤夛儌乕僯儞僌儗僋僠儍乕丏 2016擭10寧8擔, 墶昹丏
14. 嵅乆栘懽巎丆拞奯婱暥丆揷懞傒備偒丆彫嶳椙懢丆暉搰媣戙丆戝敘抭巕丆堜屗愳夒巎丆壃榓峅丆暯捤攷媊丆帪栰棽帄丏岥峯滸暯忋旂娻偵偍偗傞偑傫娭楢50堚揱巕偺曄堎夝愅丏戞75夞擔杮娻妛夛妛弍憤夛 2016擭10寧6擔, 墶昹丏
15. 堜屗愳夒巎丆戝敘抭巕丆嵅乆栘懽巎丆帪栰棽帄丏娻偵偍偗傞p53偍傛傃挿嵔旕僐乕僪RNA乮lncRNA乯偵傛傞揮幨僱僢僩儚乕僋夝愅丏戞75夞擔杮娻妛夛妛弍憤夛 2016擭10寧8擔, 墶昹丏
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17. 戝敘抭巕丆堜屗愳夒巎丆揷懞傒備偒丆拞奯婱暥丆彫嶳椙懢丆嵅乆栘懽巎丆 帪栰棽帄丏怴婯p53昗揑堚揱巕LIMA1偼娻嵶朎怹弫傪梷惂偟掅敪尰偑梊屻晄椙偲憡娭偡傞丏戞75夞擔杮娻妛夛妛弍憤夛 2016擭10寧8擔, 墶昹丏
18. 拞奯婱暥丆嵅乆栘懽巎丆堜屗愳夒巎丆彫嶳椙懢丆揷懞傒備偒丆戝敘抭巕丆壃榓峅丆暯捤攷媊丆帪栰棽帄丏師悽戙敿摫懱僔乕働儞僒乕傪梡偄偨岥峯滸暯忋旂娻偵偍偗傞偑傫娭楢堚揱巕偺栐梾揑夝愅丏戞75夞擔杮娻妛夛妛弍憤夛 2016擭10寧7擔, 墶昹丏
19. 彫嶳椙懢丆嵅乆栘懽巎丆揷懞傒備偒丆拞奯婱暥丆戝敘抭巕丆堜屗愳夒巎丆帪栰棽帄丏p53僼傽儈儕乕堚揱巕偺昗揑偲偟偰偺BRMS1L (breast cancer metastasis suppressor 1 like, BRMS1-like)偺摨掕偲婡擻夝愅丏戞75夞擔杮娻妛夛妛弍憤夛 2016擭10寧7擔, 墶昹丏
20. 暉搰媣戙丆嵅乆栘懽巎丆揷懞傒備偒丆抮揷攷丆愇崟堦栫丆烴堜峎梞丆帪栰棽帄丏師悽戙僔乕僋僄儞僒乕傪梡偄偨懡敪惈崪悜庮偵偍偗傞堚揱巕曄堎偲僐僺乕悢堎忢偺夝愅丏戞75夞擔杮娻妛夛妛弍憤夛 2016擭10寧6擔, 墶昹丏
21. 杒搱梞巙丆娵嶳楁弿丆嶳杮塸堦榊丆怴徖栆丆惵栘宧懃丆尨揷戱丆峛斻惓峀丆拠悾桾巙丆帪栰棽帄丆楅栘戱丏枬惈堓墛偍傛傃堓娻偵娭楢偡傞挿嵔noncoding RNA偺摨掕丏戞75夞擔杮娻妛夛妛弍憤夛 2016擭10寧6擔, 墶昹丏
22. 漭尠丆嶳杮塸堦榊丆捗栴揷桳搇丆峛斻惓峀丆怴徖栆丆杒搱梞巙丆惵栘宧懃丆庒悪廏庽丆帪栰棽帄丆拠悾桾巙丆楅栘戱丏戝挵娻偵偍偗傞庮釃寣娗撪旂娭楢堚揱巕偺摨掕丏戞75夞擔杮娻妛夛妛弍憤夛 2016擭10寧6擔, 墶昹丏
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29. 戝敘抭巕丆堜屗愳夒巎丆嵅乆栘懽巎丆帪栰棽帄丏LIMA1偼怴婯p53昗揑堚揱巕偱偁傝娻嵶朎怹弫傪梷惂偡傞丏戞39夞擔杮暘巕惗暔妛夛擭夛, 2016擭12寧2擔丏墶昹丏
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31. 嵅乆栘懽巎丏偑傫椞堟偵偍偗傞僋儕僯僇儖僔乕僋僄儞僗偺尰忬偲枹棃丏戞侾夞 摴撿椪彴暘巕昦懺尋媶夛丏2016擭10寧11擔丆敓娰丏

尋媶彆惉

1. 帪栰棽帄丂p53僱僢僩儚乕僋偺棟夝偲暘巕昗揑岓曗偺扵嶕丂暯惉28-30擭搙暥晹壢妛徣壢妛尋媶旓曗彆嬥乮婎斦尋媶俠乯尋媶戙昞丏
2. 帪栰棽帄丆嵅乆栘懽巎丆堜屗愳夒巎丏乽愭恑僎僲儉夝愅尋媶悇恑僾儔僢僩僼僅乕儉乿丂暯惉28-33擭搙暥晹壢妛徣壢妛尋媶旓曗彆嬥乮怴妛弍椞堟尋媶乯丂尋媶巟墖暘扴丏
3. 帪栰棽帄丂乽庮釃偺栐梾揑堚揱巕夝愅乿 暯惉26-31擭搙暥晹壢妛徣壽戣夝寛宆崅搙堛椕恖堢惉僾儘僌儔儉 擄昦崕暈師悽戙僗乕僷乕僪僋僞乕偺堢惉 NGSD僾儘僌儔儉 暘扴
4. 帪栰棽帄丏暯惉28擭搙嶥杫堛壢戝妛妛弍怳嫽帠嬈尋媶幰摍奀奜庴擖帠嬈丏
5. 嵅乆栘懽巎丏p53僼傽儈儕乕偵惂屼偝傟傞旕僐乕僪RNA偲徚壔婍敪偑傫丗暘巕昗揑偲偟偰偺壜擻惈丏暯惉26-28擭搙暥晹壢妛徣壢妛尋媶旓曗彆嬥乮婎斦尋媶C乯尋媶戙昞丏
6. 嵅乆栘懽巎丏暯惉28擭搙嶥杫堛壢戝妛摿掕堛妛尋媶悇恑帠嬈丏
7. 嵅乆栘懽巎丏暯惉28擭搙嶥杫堛壢戝妛妛弍怳嫽帠嬈尋媶幰摍奀奜攈尛帠嬈
8. 堜屗愳夒巎丏娻娭楢揮幨場巕偺昗揑旕僐乕僪RNA夝愅偵傛傞徚壔婍娻昦懺偺夝柧丏暯惉28-30擭搙暥晹壢妛徣壢妛尋媶旓曗彆嬥乮婎斦尋媶C乯尋媶戙昞丏
9. 堜屗愳夒巎丏戞30夞岞塿嵿抍朄恖庻尨婰擮嵿抍丆尋媶彆惉丏
10. 堜屗愳夒巎丆嵅乆栘懽巎丆帪栰棽帄丆媨栰屽丏暯惉28擭搙搶嫗戝妛堛壢妛尋媶強嫟摨尋媶丏
11. 戝敘抭巕丏僎僲儉栐梾揑側p53寢崌晹埵摨掕傪梡偄偨昗揑堚揱巕扵嶕偵傛傞娻昦懺偺夝柧丏擔杮妛弍怳嫽夛摿暿尋媶堳DC2乮暯惉28擭搙嵦梡乯
12. 暉搰媣戙.丂師悽戙僔乕僋僄儞僒乕傪梡偄偨懡敪惈崪悜庮偵偍偗傞堚揱巕曄堎, 僐僺乕悢堎忢偺夝愅. 暯惉28擭搙嶥杫堛壢戝妛妛弍怳嫽帠嬈彆惉丂尋媶幰摍奀奜攈尛帠嬈