2008擭乮暯惉20擭乯

榑暥

1:	LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobacter pylori-related enlarged-fold gastritis.
	Yamamoto E, Toyota M, Suzuki H, Kondo Y, Sanomura T, Murayama Y, Ohe-Toyota M, Maruyama R, Nojima M, Ashida M, Fujii K, Sasaki Y, Hayashi N, Mori M, Imai K, Tokino T, Shinomura Y. Cancer Epidemiol Biomarkers Prev. 2008 Oct;17(10):2555-64. PMID: 18842996 [PubMed - indexed for MEDLINE] Related Articles

2:	Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma.
	Takagi H, Sasaki S, Suzuki H, Toyota M, Maruyama R, Nojima M, Yamamoto H, Omata M, Tokino T, Imai K, Shinomura Y. J Gastroenterol. 2008;43(5):378-89. Epub 2008 Jul 1. PMID: 18592156 [PubMed - indexed for MEDLINE] Related Articles

3:	In vitro transformation of adult rat hepatic progenitor cells into pancreatic endocrine hormone-producing cells.
	Kawasaki H, Mizuguchi T, Kikkawa Y, Oshima H, Sasaki Y, Tokino T, Kokai Y, Miyazaki J, Katsuramaki T, Mitaka T, Hirata K. J Hepatobiliary Pancreat Surg. 2008;15(3):310-7. Epub 2008 Jun 6. PMID: 18535770 [PubMed - indexed for MEDLINE] Related Articles

4:	Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer.
	Toyota M, Suzuki H, Sasaki Y, Maruyama R, Imai K, Shinomura Y, Tokino T. Cancer Res. 2008 Jun 1;68(11):4123-32. PMID: 18519671 [PubMed - indexed for MEDLINE] Related Articles

5:	Epigenetic inactivation of SFRP genes in oral squamous cell carcinoma.
	Sogabe Y, Suzuki H, Toyota M, Ogi K, Imai T, Nojima M, Sasaki Y, Hiratsuka H, Tokino T. Int J Oncol. 2008 Jun;32(6):1253-61. PMID: 18497987 [PubMed - indexed for MEDLINE] Related Articles

6:	DNA hypermethylation contributes to incomplete synthesis of carbohydrate determinants in gastrointestinal cancer.
	Kawamura YI, Toyota M, Kawashima R, Hagiwara T, Suzuki H, Imai K, Shinomura Y, Tokino T, Kannagi R, Dohi T. Gastroenterology. 2008 Jul;135(1):142-151.e3. Epub 2008 Mar 21. PMID: 18485915 [PubMed - indexed for MEDLINE] Related Articles

7:	Histone deacetylase inhibitor FK228 enhances adenovirus-mediated p53 family gene therapy in cancer models.
	Sasaki Y, Negishi H, Idogawa M, Suzuki H, Mita H, Toyota M, Shinomura Y, Imai K, Tokino T. Mol Cancer Ther. 2008 Apr;7(4):779-87. PMID: 18413792 [PubMed - indexed for MEDLINE] Related Articles

8:	A requirement for DICER to maintain full promoter CpG island hypermethylation in human cancer cells.
	Ting AH, Suzuki H, Cope L, Schuebel KE, Lee BH, Toyota M, Imai K, Shinomura Y, Tokino T, Baylin SB. Cancer Res. 2008 Apr 15;68(8):2570-5. PMID: 18413723 [PubMed - indexed for MEDLINE] Related Articles

9:	Cytoplasmic RASSF2A is a proapoptotic mediator whose expression is epigenetically silenced in gastric cancer.
	Maruyama R, Akino K, Toyota M, Suzuki H, Imai T, Ohe-Toyota M, Yamamoto E, Nojima M, Fujikane T, Sasaki Y, Yamashita T, Watanabe Y, Hiratsuka H, Hirata K, Itoh F, Imai K, Shinomura Y, Tokino T. Carcinogenesis. 2008 Jul;29(7):1312-8. Epub 2008 Feb 29. PMID: 18310659 [PubMed - indexed for MEDLINE] Related Articles Free article in PM C | at journal site

10:	Identification of flotillin-2, a major protein on lipid rafts, as a novel target of p53 family members.
	Sasaki Y, Oshima Y, Koyama R, Maruyama R, Akashi H, Mita H, Toyota M, Shinomura Y, Imai K, Tokino T. Mol Cancer Res. 2008 Mar;6(3):395-406. Epub 2008 Feb 22. PMID: 18296650 [PubMed - indexed for MEDLINE] Related Articles

11:	Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma.
	Imai T, Toyota M, Suzuki H, Akino K, Ogi K, Sogabe Y, Kashima L, Maruyama R, Nojima M, Mita H, Sasaki Y, Itoh F, Imai K, Shinomura Y, Hiratsuka H, Tokino T. Cancer Sci. 2008 May;99(5):958-66. Epub 2008 Feb 24. PMID: 18294275 [PubMed - indexed for MEDLINE] Related Articles

12:	Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer.
	Suzuki H, Toyota M, Carraway H, Gabrielson E, Ohmura T, Fujikane T, Nishikawa N, Sogabe Y, Nojima M, Sonoda T, Mori M, Hirata K, Imai K, Shinomura Y, Baylin SB, Tokino T. Br J Cancer. 2008 Mar 25;98(6):1147-56. Epub 2008 Feb 19. Erratum in: Br J Cancer. 2008 Jul 22;99(2):384. Caraway, H [corrected to Carraway, H]. PMID: 18283316 [PubMed - indexed for MEDLINE] Related Articles

挊彂丒憤愢

1. Toyota M, Kashima L, Tokino T. CHFR as a potential anticancer target. Cancer Drug Discovery and Development Checkpoint Response in Cancer Therapy. pp163-176, Edited by Dai W, Humana Press, NJ, USA, 2008. Total pages 314.
2. Suzuki H, Tokino T, Shinomura Y, Imai K, Toyota M. DNA methylation and cancer pathways in gastrointestinal tumors. Pharmacogenomics 9: 1917-1928, 2008.
3. 堜屗愳夒巎丆帪栰棽帄丆幝懞嫳媣丆崱堜峗嶰丏徚壔婍宯幘姵偺堚揱巕妛乗徚壔婍娻偵偍偗傞miRNA 堎忢乗嵟怴堛妛 戞63姫9寧憹姧崋丂p1849-1859, 2008.
4. 朙揷幚丄嶳壓恀岾丄埳搶暥惗丄帪栰棽帄丄Bisulfite-sequencing. Surgery Frontier. 15: 184-186, 2008.

妛夛敪昞

1. Tokino T, Sasaki Y. Identification of flotillin-2, a major protein on lipid rafts, as a novel target of the p53 family members. American Association of Cancer Research (AACR) Annual meeting. 2008, San Diego, USA.
2. Idogawa M, Sasaki Y, Imai K, Shinomura Y, Tokino T. Enhancement of antitumor effect by adenovirus-mediated p53 expression with p21 suppression by miRNA. American Association of Cancer Research (AACR) annual meeting. 2008, San Diego, USA.
3. Nojima M, Yamamoto H, Suzuki H, Toyota M, Imai K, Mori M, Tokino T, Shinomura Y. LINE-1 hypomethylation is associated with increased CpG island methylation in helicobacter pylori-related enlarged fold gastritis. AACR Special Conference on Cancer Research: Cancer Epigenetics. 2008, Boston, USA.
4. Toyota M, The role of DNA methylation changes in signaling pathway. AACR Special Conference on Cancer Research: Cancer Epigenetics, 2008, Boston, USA.
5. Toyota M, Suzuki H, Tokino T, Shinomura Y, Imai K Epigenetic Gene Silencing and microRNA in Human Colon Cancer. The 36th Meeting of the International Society of Oncology and BioMarkers. 2008, Tokyo, Japan.
6. Sasaki Y, Idogawa M, Suzuki M, Mita H, Toyota M, Shinomura Y, Imai K, Tokino T. Histone Deacetylase Inhibitor FK228 Enhances Adenovirus-mediated p53 Family Gene Therapy in Cancer Models. The 36th Meeting of the International Society of Oncology and BioMarkers. 2008, Tokyo, Japan.
7. Yamashita M, Suzuki H, Nojima M, Igarashi S, Shinomura Y, Imai K, Tokino T, Itoh F, Toyota M. Epigenetic Silencing of Interferon Regulatory Factor(IRF) Family Genes in Colorectal and Gastric Cancer. The 36th Meeting of the International Society of Oncology and BioMarkers. 2008, Tokyo, Japan.
8. Idogawa M, Sasaki Y, Imai K, Shinomura Y, Tokino T. p53 expression with p21 suppression by single vector enhances antitumor effect. The 36th Meeting of the International Society of Oncology and BioMarkers. 2008, Tokyo, Japan
9. Mita H, Aoki F, Akashi H, Maruyama R, Sasaki Y, Suzuki H, Idogawa M, Kashima L, Toyota M, Imai K, Shinomura Y, Tokino T. Genomic Mapping of 12p Amplifications in Gastric Cancer Reveal a 0.5-Mb Target Region Including KRAS Locus. The 36th Meeting of the International Society of Oncology and BioMarkers. 2008, Tokyo, Japan
10. Nojima M, Yamamoto E, Toyota M, Suzuki H, Kondo Y, Sanomura T, Murayama Y, Ohe-Toyota M, Maruyama R, Ashida M, Fujii K, Sasaki Y, Hayashi N, Mori M, Imai K, Tokino T, Shinomura Y. LINE-1 Hypomethylation is Associated with Increased CpG Island Methylation in H. pylori-related Enlarged Fold Gastritis. The 36th Meeting of the International Society of Oncology and BioMarkers. 2008, Tokyo, Japan
11. 嵅乆栘懽巎丆埨曐捈庽丆崻娸廏柧丆堜屗愳夒巎丆尒揷桾復丆朙揷幚丆崱堜峗嶰丆幝懞嫳媣丆帪栰棽帄丏p53僼傽儈儕乕乮p73丆p63乯偺昗揑堚揱巕apolipoprotein D偺摨掕丏戞67夞擔杮娻妛夛妛弍憤夛丏2008丏柤屆壆丏
12. 嶳杮塸堦榊丆朙揷幚丆楅栘戱丆栰搰惓姲丆娵嶳楀弿丆屲廫棐怢堦丆帪栰棽帄丆崱堜峗嶰丆幝懞嫳媣丏岚妩旍戝宆堓墛偵偍偗傞僎僲儉儚僀僪側掅儊僠儖壔偲CpG傾僀儔儞僪崅儊僠儖壔偺娭楢丏戞67夞擔杮娻妛夛妛弍憤夛丏2008丏柤屆壆丏
13. 楅栘戱丆朙揷幚丆栰搰惓姲丆嵅乆栘懽巎丆帪栰棽帄丆崱堜峗嶰丆幝懞嫳媣丏戝挵娻偵偍偗傞microRNA-34b/c偍傛傃BTG4偺CpG傾僀儔儞僪儊僠儖壔偵傛傞僄僺僕僃僱僥傿僢僋側晄妶壔丏戞67夞擔杮娻妛夛妛弍憤夛丏2008丏柤屆壆丏
14. 屲廫棐怢堦丆楅栘戱丆朙揷幚丆帪栰棽帄丆崱堜峗嶰丆幝懞嫳媣丏娻嵶朎偺堚揱巕CpG傾僀儖儔儞僪儊僠儖壔偺堐帩偵偍偗傞DICER偺昁梫惈丏戞67夞擔杮娻妛夛妛弍憤夛丏2008丏柤屆壆丏
15. 埨曐捈庽丆嵅乆栘懽巎丆崻娸廏柧丆堜屗愳夒巎丆彫嶳椙懢丆朙揷幚丆楅栘戱丆帪栰棽帄丏p53偵傛傞娞娻桼棃憹怋場巕乮HDGF乯偺梷惂婡峔丏戞67夞擔杮娻妛夛妛弍憤夛丏2008丏柤屆壆丏
16. 尒揷桾復丆朙揷幚丆惵栘暥晇丆柧愇峗巎丆娵嶳楀弿丆嵅乆栘懽巎丆楅栘戱丆堜屗愳夒巎丆幁搰棟嵐丆僒僶僂僜儕儞丆崱堜峗嶰丆幝懞嫳媣丆帪栰棽帄丏堓娻偵偍偗傞KRAS堚揱巕憹暆偲嵶朎撪僔僌僫儖偺妶惈壔丏戞67夞擔杮娻妛夛妛弍憤夛丏2008丏柤屆壆丏
17. 栰搰惓姲丆朙揷幚丆娵嶳楀弿丆楅栘戱丆椦晀徍丆愇揷掯晇丆庰堜婎丆杻墱塸婤丆帪栰棽帄丆崱堜峗嶰丆幝懞嫳媣丏懡敪惈崪悜庮偵偍偗傞DNA堎忢儊僠儖壔偺栐梾揑夝愅偲怴婯儊僠儖壔昗揑堚揱巕RASD1丏戞67夞擔杮娻妛夛妛弍憤夛丏2008丏柤屆壆丏
18. 摗寭抭巕丆朙揷幚丆楅栘戱丆惣愳婭巕丆戝懞搶惗丆惣娳晀旻丆嵅乆栘懽巎丆暯揷岞堦丆帪栰棽帄丏擕娻偵偍偄偰DNA儊僠儖壔偵傛傝晄妶壔偝傟傞堚揱巕偺僎僲儉栐梾揑夝愅丏戞67夞擔杮娻妛夛妛弍憤夛丏2008丏柤屆壆丏
19. 嶳壓恀岾丆楅栘戱丆栰搰惓姲丆屲廫棐怢堦丆崱堜峗嶰丆幝懞嫳媣丆帪栰棽帄丆埳摗暥惗丆朙揷幚丏徚壔婍娻偵偍偗傞IRF僼傽儈儕乕偺僄僺僕僃僱僥傿僢僋側堎忢偲堄媊丏戞67夞擔杮娻妛夛妛弍憤夛丏2008丏柤屆壆丏
20. 慮変晹梲暯丆楅栘戱丆朙揷幚丆崱堜悞丆栰搰惓姲丆嵅乆栘懽巎丆帪栰棽帄丆暯捤攷媊丏岥峯滸暯忋旂娻偵偍偗傞SFRP堚揱巕偺僄僺僕僃僱僥傿僢僋側晄妶壔丏戞67夞擔杮娻妛夛妛弍憤夛丏2008丏柤屆壆丏
21. 堜屗愳夒巎丆嵅乆栘懽巎丆崱堜峗嶰丆幝懞嫳媣丆帪栰棽帄丏miRNA偵傛傞p21桿摫梷惂擻傪傕偮p53敪尰傾僨僲僂僀儖僗儀僋僞乕偵傛傞峈庮釃岠壥偺憹嫮丏戞67夞擔杮娻妛夛妛弍憤夛丏2008丏柤屆壆丏
22. 朙揷幚丆楅栘戱丆幝懞嫳媣丆帪栰棽帄丆崱堜峗嶰丏戝挵娻偺僔僌僫儖宱楬堎忢偵偍偗傞DNA儊僠儖壔偺栶妱丏戞67夞擔杮娻妛夛妛弍憤夛丏2008丏柤屆壆丏
23. 幁搰棟嵐丆尒揷桾復丆朙揷幚丆嵅乆栘懽巎丆楅栘戱丆堜屗愳夒巎丆帪栰棽帄丏CHFR偼NF-kappaB傪梷惂偡傞丏戞67夞擔杮娻妛夛妛弍憤夛丏2008丏柤屆壆丏
24. 朙揷幚丆楅栘戱丆幝懞嫳媣丆帪栰棽帄丏娻偵偍偗傞僄僺僕僃僱僥傿僢僋側堎忢偺栐梾揑夝愅丏戞31夞擔杮暘巕惗暔妛夛擭夛丏2008丏恄屗丏
25. Sasaki Y, Negishi H, Anbo N, Suzuki H, Toyota M, Tokino T. Negative regulation of hepatoma-derived growth factor by p53. The 31st annual Meeting of the Molecular Biology Society of Japan. 2008, Kobe.
26. Nojima M, Toyota M, Hiromu Suzuki, Takashi Tokino, Yasuhisa Shinomura. The positive transcription elongation factor b is an essential co-factor for the activation of transcription by myoctyte enhancer factor 2. The 31st annual Meeting of the Molecular Biology Society of Japan. 2008, Kobe.
27. 楅栘戱丆朙揷幚丆栰搰惓姲丆帪栰棽帄丆崱堜峗嶰丆幝懞嫳媣丏戝挵娻偵偍偗傞microRNA-34b/c偺僄僺僕僃僱僥傿僢僋側晄妶壔丏戞31夞擔杮暘巕惗暔妛夛擭夛丏2008丏恄屗丏
28. 幁搰棟嵐, 尒揷桾復, 朙揷幚, 嵅乆栘懽巎, 楅栘戱, 堜屗愳夒巎, 帪栰棽帄. CHFR mitotic checkpoint protein inhibits the transcriptional activity of NF-kB. 擔杮暘巕惗暔妛夛戞8夞弔婫僔儞億僕僂儉. 2008, 嶥杫.
29. 尒揷 桾復丄嵅乆栘 懽巎丄堜屗愳 夒巎丄幁搰 棟嵐丄柧愇 峗巎丄惵栘 暥晇丄娵嶳 楁弿丄楅栘 戱丄朙揷 幚丄崱堜 峗嶰丄幝懞 嫳媣丄帪栰 棽帄. 堓娻偵偍偗傞KRAS堚揱巕憹暆偲嵶朎撪僔僌僫儖揱払偺夝愅. 擔杮暘巕惗暔妛夛戞8夞弔婫僔儞億僕僂儉. 2008, 嶥杫.
30. 嵅乆栘懽巎丏p53堚揱巕僼傽儈儕乕偺婡擻夝愅偲娻帯椕傊偺墳梡丏暯惉19擭搙摿掕堛妛尋媶悇恑帠嬈偵學傞尋媶惉壥曬崘夛丏2008, 嶥杫

尋媶彆惉

1. 帪栰棽帄丆壃榓峅丆暯捤攷媊丏嵶朎暘楐惂屼堚揱巕CHFR偺婡擻夝柧偍傛傃岥峯娻偺恌抐偲暘巕昗揑栻偺奐敪傊偺墳梡丏暯惉20-22擭搙暥晹壢妛徣壢妛尋媶旓曗彆嬥乮婎斦尋媶B乯丏
2. 帪栰棽帄丏p53僼傽儈儕乕偺婡擻夝愅偲偑傫帯椕傊偺墳梡丏暯惉17-21擭搙暥晹壢妛徣壢妛尋媶旓曗彆嬥乮摿掕椞堟尋媶乯丏
3. 帪栰棽帄丆屆敤抭媣丆尒揷桾復丆柧愇峗巎丏僨僕僞儖 僎僲儉 僗僉儍僯儞僌朄偺奐敪偲堓娻娭楢堚揱巕扵嶕傊偺墳梡丏暯惉19-20擭搙暥晹壢妛徣壢妛尋媶旓曗彆嬥乮朑夎尋媶乯丏
4. 嵅乆栘懽巎丏儕儃僝乕櫻抈敀幙偺敪尰堎忢傪昗揑偲偟偨徚壔婍娻偵懳偡傞恌抐丒帯椕朄偺奐敪丏暯惉20-22擭搙暥晹壢妛徣壢妛尋媶旓曗彆嬥乮婎斦尋媶C乯丏
5. 嵅乆栘懽巎丏p53揮幨惂屼場巕僼傽儈儕乕偵傛偭偰巟攝偝傟傞婡擻惈RNA偺夝愅丏戞23夞乮暯惉20擭搙乯庻尨婰擮嵿抍尋媶彆惉嬥丏
6. 嵅乆栘懽巎丏p53桿摫惈儅僀僋儘RNA傪昗揑偲偟偨娻偺恌抐丒帯椕朄偺奐敪丏嶥杫堛壢戝妛妛弍怳嫽彆惉丂暯惉20擭搙嫵堢尋媶彆惉丏
7. 尒揷桾復. 僎僲儉僐僺乕悢曄摦傪昗揑偲偟偨徚壔婍娻偺怴婯暘巕昗揑帯椕偺奐敪丏暯惉20擭搙暥晹壢妛徣壢妛尋媶旓曗彆嬥乮婎斦尋媶C乯丏
8. 堜屗愳夒巎丏miRNA偵傛傞堚揱巕敪尰梷惂擻傪晅壛偟偨p53傾僨僲僂僀儖僗偵傛傞娻帯椕偺奐敪丏暯惉20-21擭搙暥晹壢妛徣壢妛尋媶旓曗彆嬥乮庒庤尋媶B乯丏
9. 堜屗愳夒巎丏 miRNA偵傛傞p21敪尰梷惂擻傪旛偊偨p53敪尰儀僋僞乕偵傛傞偑傫帯椕岠壥偺夵慞丏嵿抍朄恖搾愺婰擮夛丂暯惉20擭搙榑暥摍挷嵏尋媶彆惉嬥丏
10. 堜屗愳夒巎丏miRNA偵傛傞p21敪尰桿摫梷惂擻傪晅壛偟偨p53敪尰傾僨僲僂僀儖僗偵傛傞娻帯椕岠壥偺憹嫮丏暯惉20擭搙嶥杫堛壢戝妛摿掕堛妛尋媶悇恑帠嬈旓乮彠椼揑尋媶乯丏
11. 堜屗愳夒巎丏 miRNA偵傛傞p21敪尰桿摫梷惂擻傪晅壛偟偨p53敪尰儀僋僞乕偵傛傞娻帯椕岠壥偺憹嫮丏嶥杫堛壢戝妛妛弍怳嫽彆惉丂暯惉20擭搙嫵堢尋媶彆惉丏
12. 幁搰棟嵐丏CHFR偺怴婯婡擻NF-kB梷惂丆庮釃梷惂丏嶥杫堛壢戝妛妛弍怳嫽彆惉丂暯惉20擭搙嫵堢尋媶彆惉丏
13. 埨曐捈庽丆嵅乆栘懽巎丏p53偵惂屼偝傟傞婡擻惈RNA傪昗揑偵偟偨娻偺恌抐丒帯椕朄偺奐敪丏暯惉20擭搙嶥杫堛壢戝妛摿掕堛妛尋媶悇恑帠嬈旓乮彠椼揑尋媶乯丏
14. 朙揷幚丄偑傫偺敪惗偲恑揥偵偍偗傞DNA儊僠儖壔偍傛傃僸僗僩儞廋忺堎忢偺栶妱. 暯惉17-21擭搙暥晹壢妛徣壢妛尋媶旓曗彆嬥乮摿掕椞堟尋媶乯.
15. 朙揷幚丄怴婯僄僺僎僲儉夝愅媄弍偺奐敪偲徚壔婍娻偺屄惈恌抐丒屄暿壔帯椕傊偺墳梡. 暯惉19-20擭搙暥晹壢妛徣壢妛尋媶曗彆嬥 (婎斦尋媶 B) .
16. 崱堜峗嶰丄朙揷幚丄嶳杮攷岾丄幝懞嫳媣. 僄僺僕僃僱僥傿僢僋側堎忢偵傛傞徚壔婍娻敪惗偺暘巕婡峔偲恌抐丒帯椕傊偺墳梡, 暯惉17亅21擭搙暥晹壢妛徣壢妛尋媶曗彆嬥 (婎斦尋媶 S).

庴丂徿

1. 楅栘戱丗戝挵娻偵偍偗傞microRNA-34b/c偺僄僺僕僃僱僥傿僢僋側晄妶惈壔丏戞19夞擔杮徚壔婍娻敪惗妛夛憤夛嵟桪廏徿丏