業績

2025年

英文

? Norihiro Imai , Yuki Ohsaki , Jinglei Cheng, Hanna Kawecka, Jingjing Zhang, Fumitaka Mizuno, Taku Tanaka, Shinya Yokoyama, Kenta Yamamoto, Takanori Ito, Yoji Ishizu, Takashi Honda, Tetsuya Ishikawa, Micha? Wo?niak 4, Hiroaki Wake 3, Hiroki Kawashima 1
Hepatol Res. 2025 May 10. doi: 10.1111/hepr.14195. Online ahead of print.
Pathological significance of intranuclear structures in liver biopsy samples.
PMID: 40347491
 
?Atsushi Sawada , Tatsuya Kunigo, Yuki Ohsaki, Kanna Nagaishi, Michiaki Yamakage
J Anesth. 2025 Apr 17. doi: 10.1007/s00540-025-03503-z. Online ahead of print.
PMID: 40244392
 
?Tatsuya Kunigo , Yusuke Yoshikawa, Shunichi Niki, Masahiro Ohtani , Mami Muraki, Asako Nitta, Yuki Ohsaki, Kanna Nagaishi, Michiaki Yamakage
J Clin Anesth.　 2025 Feb:101:111740.　 doi: 10.1016/j.jclinane.2024.111740. Epub 2025 Jan 3.
Ultrasound-assisted middle thoracic epidural catheter placement utilizing the most dorsal sites of bilateral transverse process roots as anatomical landmarks: A cadaveric observational study and a clinical randomized controlled trial.
PMID: 39752792 
 
?Gakuto Nakao, Kazuma Yamagata, Risa Adachi, Koki Ishiyama, Kazuyoshi Kozawa, Kota Watanabe, Yuki Ohsaki, Kousuke Shiwaku, Norio Hayashi, Masaki Katayose, Keigo Taniguchi
J Biomech. 2025 Jan:179:112480. doi: 10.1016/j.jbiomech.2024.112480. Epub 2024 Dec 13.
Passive muscle tension changes in the biceps femoris long head after biceps femoris short head detachment: A human cadaver study.
PMID: 39693787

和文

 ?高野敦郎、原田智紀、日野浩嗣、原弘之、相澤信、平井宗一：　三次元培養の技術と活用　日大医学雑誌, 84: 13-18, 2025
 

トップに戻る

2024年

英文

 ?Gakuto Nakao, Taiki Kodesho , Kazuma Yamagata , Kota Watanabe, Yuki Ohsaki, Masaki Katayose , Keigo Taniguchi, Gakuto Nakao, Taiki Kodesho , Kazuma Yamagata , Kota Watanabe , Yuki Ohsaki , Masaki Katayose , Keigo Taniguchi 
Cureus. 2024 Aug 31;16(8):e68343. doi: 10.7759/cureus.68343. eCollection 2024 Aug.
Validity of Elastic Imaging Evaluation of Hamstring Muscles With Knee Contracture Using Ultrasound Shear Wave Elastography.
PMID: 39355060 PMCID: PMC11442639
 
?Gakuto Nakao, Taiki Kodesho, Takuya Kato, Yu Yokoyama, Yuhei Saito, Yuki Ohsaki , Kota Watanabe , Masaki Katayose , Keigo Taniguchi
Published Erratum J Med Ultrason (2001)
J Med Ultrason (2001). 2024 Jul;51(3):541. doi: 10.1007/s10396-024-01436-w.
Correction: Relationship between shear elastic modulus and passive muscle force in human hamstring muscles using a Thiel soft-embalmed cadaver.
PMID: 38507155 PMCID: PMC11272735
 
?Gakuto Nakao, Taiki Kodesho, Kazuma Yamagata , Kota Watanabe, Yuki Ohsaki, Masaki Katayose , Keigo Taniguchi 
J Mech Behav Biomed Mater. 2024 May:153:106473. doi: 10.1016/j.jmbbm.2024.106473. Epub 2024 Feb 28.
Stress-strain relationship of individual hamstring muscles: A human cadaver study.
PMID: 38452573

?Yoshinori Tanaka, Lina Kozuma, Hirotsugu Hino, Kosuke Takeya, Masumi Eto Abemaciclib and Vacuolin-1 decrease aggregate-prone TDP-43 accumulation by accelerating autophagic flux　
Biochem Biophys Rep. 2024 Apr 1:38:101705. doi: 10.1016/j.bbrep.2024.101705. eCollection 2024 Jul.PMID: 38596406

?Toshikatsu Ikeda, Yuki Katoh, Hirotsugu Hino, Daichi Seta, Tadashi Ogawa, 
Takashi Iwata, Hiroshi Nishio, Masaki Sugawara, Shuichi Hirai　FADS2 confers SCD1 inhibition resistance to cancer cells by modulating the ER stress response　Sci Rep. 2024 Jun 7;14(1):13116. doi: 10.1038/s41598-024-64043-2.PMID: 38849435
 
?Hirotsugu Hino, Kaori Takaki, Mika Kobe, Satoru Mochida　Development of luminescent probes for real-time detection of the CDK/PP2A balance during the cell cycle　Genes Cells. 2024 Nov;29(11):1002-1011. doi: 10.1111/gtc.13159. Epub 2024 Sep 11.PMID: 39262142

和文

 ?沖本智哉、日野浩嗣、平井　宗一　CRISPR/Cas9 による遺伝子改変技術
日大医学雑誌, 83: 121-126, 2024

トップに戻る

2023年

英文

  • Satoshi Hirako, Nobuhiro Wada, Yuzuru Iizuka , Takahiro Hirabayashi , Haruaki Kageyama , Hyounju Kim , Naoko Kaibara , Naoko Yanagisawa , Fumiko Takenoya , Seiji Shioda.Effect of Intracerebroventricular Administration of Galanin-Like Peptide on Hepatokines in C57BL/6 J Mice
    J Mol Neurosci. 2024 Feb 22;74(1):25. doi: 10.1007/s12031-024-02200-y.Affiliations expand PMID: 38386221 DOI: 10.1007/s12031-024-02200-y
  • Takumi Konno , Takayuki Kohno , Shin Kikuchi , Arisa Kura , Kimihito Saito , Tadahi Okada , Hiroshi Shimada , Yuya Yamazaki , Tomoki Sugiyama, Motoki Matsuura , Yuki Ohsaki, Tsuyoshi Saito, Takashi Kojima. The interplay between the epithelial permeability barrier, cell migration and mitochondrial metabolism of growth factors and their inhibitors in a human endometrial carcinoma cell line　Tissue Barriers　2024 Jan 15:2304443. doi: 10.1080/21688370.2024.2304443. Online ahead of print.
    Affiliations expand　PMID: 38225862 DOI: 10.1080/21688370.2024.2304443
  • Yuzuru Iizuka, Satoshi Hirako, Hyounju Kim, Nobuhiro Wada, Yuki Ohsaki, Naoko Yanagisawa. Fish oil-derived n-3 polyunsaturated fatty acids downregulate aquaporin 9 protein expression of liver and white adipose tissues in diabetic KK mice and 3T3-L1 adipocytes. J Nutr Biochem. 2023 Oct 31:109514. doi: 10.1016/j.jnutbio.2023.109514. Online ahead of print.

  • Tomohiro Chaki, Shunsuke Tachibana, Sho Kumita, Satoshi Sato, Tomoki Hirahata, Yuta Ikeshima, Yuki Ohsaki, Michiaki Yamakage. I-gel Plus acts as a superior conduit for fiberoptic intubation than standard i-gel.  Sci Rep. 2023 Oct 26;13(1):18381. doi: 10.1038/s41598-023-45631-0.

  • Satoshi Hirako, Yoshihiro Wakayama, Hyounju Kim, Yuzuru Iizuka, Nobuhiro Wada, Naoko Kaibara, Mai Okabe, Satoru Arata, Akiyo Matsumoto. Association of Aquaporin 7 and 9 with Obesity and Fatty Liver in db/db Mice. Zoological Science, 40(6): (2023). https://doi.org/10.2108/zs230037
  • Hirako, S., T. Hirabayashi, J. Shibato, A. Kimura, M. Yamashita, Y. Iizuka, N. Wada, N. Kaibara, F. Takenoya, and S. Shioda. 2023. Docosapentaenoic acid-rich oil lowers plasma glucose and lipids in a mouse model of diabetes and mild obesity. Nutr. Res. 118:128–136. doi:10.1016/j.nutres.2023.08.004.
  • Nakao, G., T. Kodesho, T. Kato, Y. Yokoyama, Y. Saito, Y. Ohsaki, K. Watanabe, M. Katayose, and K. Taniguchi. 2023. Relationship between shear elastic modulus and passive muscle force in human hamstring muscles using a Thiel soft-embalmed cadaver. J. Me?d. Ultrason. 50:275–283. doi:10.1007/s10396-023-01317-8.
  • Imai, N., Y. Ohsaki, J. Cheng, J. Zhang, F. Mizuno, T. Tanaka, S. Yokoyama, K. Yamamoto, T. Ito, Y. Ishizu, T. Honda, M. Ishigami, H. Wake, and H. Kawashima. 2023. Distinct features of two lipid droplets types in cell nuclei from patients with liver diseases. Sci. Rep. 13:6851. doi:10.1038/s41598-023-33977-4.
  • Umaru, B.A., Y. Kagawa, Y. Ohsaki, Y. Pan, C.T. Chen, D.K. Chen, T. Abe, S.K. Shil, H. Miyazaki, S. Kobayashi, M. Maekawa, Y. Yamamoto, T. Wannakul, S. Yang, R.P. Bazinet, and Y. Owada. 2023. Oleic acid‐bound FABP7 drives glioma cell proliferation through regulation of nuclear lipid droplet formation. FEBS J. 290:1798–1821. doi:10.1111/febs.16672.
  • Kikuchi S, Kohno T, Kojima T, Tatsumi H, Ohsaki Y, Ninomiya T. Oxygen-Glucose Deprivation Decreases the Motility and Length of Axonal Mitochondria in Cultured Dorsal Root Ganglion Cells of Rats. Cell Mol Neurobiol. 2023 Apr;43(3):1267-1280. doi: 10.1007/s10571-022-01247-y. PMID: 35771293. 
  • Shota Moriya, Hiromi Kazama, Hirotsugu Hino, Naoharu Takano, Masaki Hiramoto, Shin Aizawa, Keisuke Miyazawa Clarithromycin overcomes stromal cell-mediated drug resistance against proteasome inhibitors in myeloma cells via autophagy flux blockage leading to high NOXA expression  PMID: 38039297
    PLoS One. 2023 Dec 1;18(12):e0295273. doi: 10.1371/journal.pone.0295273. eCollection 2023.
  • Naoharu Takano, Masaki Hiramoto, Yumiko Yamada, Hiroko Kokuba, Mayumi Tokuhisa, Hirotsugu Hino, Keisuke Miyazawa Azithromycin, a potent autophagy inhibitor for cancer therapy, perturbs cytoskeletal protein dynamics   PMID: 36871041
    Br J Cancer. 2023 May;128(10):1838-1849. doi: 10.1038/s41416-023-02210-4. Epub 2023 Mar 4.
  • Yoshitaka Sakurai , Naoto Kubota , Iseki Takamoto , Nobuhiro Wada , Masakazu Aihara , Takanori Hayashi , Tetsuya Kubota , Yuta Hiraike , Takayoshi Sasako , Harumi Nakao , Atsu Aiba , Yoko Chikaoka , Takeshi Kawamura , Takashi Kadowaki , Toshimasa Yamauchi 　Affiliations expand
    Overexpression of UBE2E2 in mouse pancreatic β-cells leads to glucose intolerance via reduction of the β-cell mass　PMID: 38064504
    DOI: 10.2337/db23-0150  

  •  Hayashi, T., N. Wada, T. Kubota, C. Koizumi, Y. Sakurai, M. Aihara, S. Usami, T. Yamauchi, and N. Kubota. 2023. Associations of sleep quality with the skeletal muscle strength in  patients with type 2 diabetes with poor glycemic control. J Diabetes Invest. doi:10.1111/jdi.14007.
  • Kodesho, T., T. Kato, G. Nakao, Y. Yokoyama, Y. Saito, K. Watanabe, Y. Ohsaki, M. Katayose, and K. Taniguchi. 2023. Effects of superficial tissue and intermuscular connections on rectus femoris muscle shear modulus heterogeneity. J Ultrasound. 1–7. doi:10.1007/s40477-022-00769-x.

トップに戻る

2022年

英文

  • Sawada, A., S. Kumita, A. Nitta, Y. Ohsaki, and M. Yamakage. 2023. Modified thoracoabdominal nerve block through perichondrial approach (M-TAPA): an anatomical study to evaluate the spread of dye after a simulated injection in soft embalmed Thiel cadavers. Regional Anesthesia Pain Medicine. rapm-2022-104275. doi:10.1136/rapm-2022-104275.
  • Banlanjo Abdulaziz Umaru , Yoshiteru Kagawa, Yuki Ohsaki , Yijun Pan  Chuck T Chen , Daniel K Chen , Toshiaki Abe , Subrata Kumar Shil , Hirofumi Miyazaki , Shuhei Kobayashi , Motoko Maekawa , Yui Yamamoto , Tunyanat Wannakul , Shuhan Yang , Richard P Bazinet , Yuji Owada.　Oleic acid-bound FABP7 drives glioma cell proliferation through regulation of nuclear lipid droplet formationFEBS J. 2022 Nov 3.  doi: 10.1111/febs.16672. 
  • Isobe, M., Y. Suzuki, H. Sugiura, M. Shibata, Y. Ohsaki, and S. Kametaka. Novel cell-based system to assay cell-cell fusion during myotube formation. 2022. Biomed Res. 43:107-114. doi:10.2220/biomedres.43.107.
  • Kakuki, T., T. Kohno, S. Nishida, T. Konno, S. Kikuchi, K. Ohwada, M. Nakano, M. Tezuka, K. Takano, and T. Kojima. 2022. FOXO3/TGF-β signal-dependent ciliogenesis and cell functions during differentiation of temperature-sensitive mouse cochlear precursor hair cells. Histochem Cell Biol. 157:415–426. doi:10.1007/s00418-021-02068-8.
  • Kikuchi, S., T. Kohno, T. Kojima, H. Tatsumi, Y. Ohsaki and T. Ninomiya. 2022. Oxygen-Glucose Deprivation Decreases the Motility and Length of Axonal Mitochondria in Cultured Dorsal Root Ganglion Cells of Rats. Cell Mol Neurobiol. doi:10.1007/s10571-022-01247-y (advance online publication)
  • Nakano, M., K. Ohwada, Y. Shindo, T. Konno, T. Kohno, S. Kikuchi, M. Tsujiwaki, D. Ishii, S. Nishida, T. Kakuki, K. Obata, R. Miyata, M. Kurose, A. Kondoh, K. Takano and T.  Kojima. 2022. Inhibition of HDAC and Signal Transduction Pathways Induces Tight Junctions and Promotes Differentiation in p63-Positive Salivary Duct Adenocarcinoma. Cancers, 14(11), 2584. doi:10.3390/cancers14112584
  • Iwamoto, M., T. Kubota, Y. Sakurai, N. Wada, S. Shioda, T. Yamauchi, T. Kadowaki, and N. Kubota. 2022. The sodium-glucose co-transporter 2 inhibitor tofogliflozin suppresses atherosclerosis through glucose lowering in ApoE-deficient mice with streptozotocin-induced diabetes. Pharmacol Res Perspectives. doi:10.1002/prp2.971.
  • Miyuki Yuda, Shin Aizawa, Isao Tsuboi, Yoko Hirabayashi, Tomonori Harada,Hirotsugu Hino, Shuichi Hirai
    Imbalanced M1 and M2 macrophage polarization in bone marrow provokes impairment of the hematopoietic microenvironment in a mouse model of hemophagocytic lymphohistiocytosis    PMID: 36328495
    Biol Pharm Bull. 2022;45(11):1602-1608. doi: 10.1248/bpb.b22-00108.
  • Yoshinori Tanaka, Hirotsugu Hino, Kosuke Takeya, Masumi Eto Abemaciclib and Vacuolin-1 induce vacuole-like autolysosome formation - A new tool to 
    study autophagosome-lysosome fusion   PMID: 35598430
    Biochem Biophys Res Commun. 2022 Jul 23:614:191-197. doi: 10.1016/j.bbrc.2022.05.027. Epub 2022 May 14.

トップに戻る

2021年

英文

  • Ando, R., K. Taniguchi, S. Kikuchi, S. Mizoguchi, M. Fujimiya, M. Katayose, and H. Akima. 2021. Sarcomere length of the vastus intermedius with the knee joint angle change. Physiological Reports. 9:e14771. doi:10.14814/phy2.14771.
  • Kohno, T., T. Konno, S. Kikuchi, M. Kondoh, and T. Kojima. 2021. Translocation of LSR from tricellular corners causes macropinocytosis at cell–cell interface as a trigger for breaking out of contact inhibition. Faseb J. 35:e21742. doi:10.1096/fj.202100299r.
  • Kojima, T., Y. Shindo, T. Konno, Y. Kodera, W. Arai, M. Miyakawa, K. Ohwada, H. Tanaka, M. Tsujiwaki, Y. Sakuma, S. Kikuchi, T. Ohkuni, K. Takano, A. Watanabe, and T. Kohno. 2021. Dysfunction of epithelial permeability barrier induced by HMGB1 in 2.5D cultures of human epithelial cells. Tissue Barriers. 10:1972760. doi:10.1080/21688370.2021.1972760.
  • Kitaoka, Y., M. Miyazaki, and S. Kikuchi. 2021. Voluntary exercise prevents abnormal muscle mitochondrial morphology in cancer cachexia mice. Physiological Reports. 9:e15016. doi:10.14814/phy2.15016.
  • Komuro, Y., L. Galas, Y.M. Morozov, J.K. Fahrion, E. Raoult, A. Lebon, A.K. Tilot, S. Kikuchi, N. Ohno, D. Vaudry, P. Rakic, and H. Komuro. 2021. The Role of Galanin in Cerebellar Granule Cell Migration in the Early Postnatal Mouse during Normal Development and after Injury. J Neurosci Official J Soc Neurosci. 41:8725–8741. doi:10.1523/jneurosci.0900-15.2021.
  • Shimada, H., T. Kohno, T. Konno, T. Okada, K. Saito, Y. Shindo, S. Kikuchi, M. Tsujiwaki, M. Ogawa, M. Matsuura, T. Saito, and T. Kojima. 2021. The Roles of Tricellular Tight Junction Protein Angulin-1/Lipolysis-Stimulated Lipoprotein Receptor (LSR) in Endometriosis and Endometrioid-Endometrial Carcinoma. Cancers. 13:6341. doi:10.3390/cancers13246341.
  • So?tysik, K., Y. Ohsaki, T. Tatematsu, J. Cheng, A. Maeda, S. Morita, and T. Fujimoto. 2021. Nuclear lipid droplets form in the inner nuclear membrane in a seipin-independent manner. J Cell Biol. 220:e202005026. doi:10.1083/jcb.202005026.
  • Tanimizu, N., N. Ichinohe, Y. Sasaki, T. Itoh, R. Sudo, T. Yamaguchi, T. Katsuda, T. Ninomiya, T. Tokino, T. Ochiya, A. Miyajima, and T. Mitaka. 2021. Generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo. Nat Commun. 12:3390. doi:10.1038/s41467-021-23575-1.
  • Wada, N. 2021a. Handbook of Hormones. 353–354. doi:10.1016/b978-0-12-820649-2.00091-7.
  • Wada, N. 2021b. Handbook of Hormones. 573–575. doi:10.1016/b978-0-12-820649-2.00146-7.
  • Wada, N. 2021c. Handbook of Hormones. 361–362. doi:10.1016/b978-0-12-820649-2.00094-2.
  • Tomonori Harada, Isao Tsuboi, Hirotsugu Hino, Miyuki Yuda, Yoko Hirabayashi, Shuichi Hirai, Shin Aizawa Age-related exacerbation of hematopoietic organ damage induced by systemic hyper-inflammation in senescence-accelerated mice
    PMID: 34853370
    Sci Rep. 2021 Dec 1;11(1):23250. doi: 10.1038/s41598-021-02621-4.
  • Masaya Miyazaki, Masaki Hiramoto, Naoharu Takano, Hiroko Kokuba, Jun Takemura, Mayumi Tokuhisa, Hirotsugu Hino, Hiromi Kazama, Keisuke Miyazawa Targeted disruption of GAK stagnates autophagic flux by disturbing lysosomal dynamics
    PMID: 34468012
    Int J Mol Med. 2021 Oct;48(4):195. doi: 10.3892/ijmm.2021.5028. Epub 2021 Sep 1.
  • Kana Miyahara, Naoharu Takano, Yumiko Yamada, Hiromi Kazama, Mayumi Tokuhisa, Hirotsugu Hino, Koji Fujita, Edward Barroga, Masaki Hiramoto, Hiroshi Handa, Masahiko Kuroda, Takashi Ishikawa, Keisuke Miyazawa BRCA1 degradation in response to mitochondrial damage in breast cancer cells 
    PMID: 33888730
    Sci Rep. 2021 Apr 22;11(1):8735. doi: 10.1038/s41598-021-87698-7.
  • Mierxiati Saimi, Shota Moriya, Zhong-Lian Li, Hidenobu Miyaso, Kenta Nagahori, Shinichi Kawata, Takuya Omotehara, Yuki Ogawa, Hirotsugu Hino, Keisuke Miyazawa, Kou Sakabe, Masahiro Itoh Cytonuclear Estrogen Receptor Alpha Regulates Proliferation and Migration of Endometrial Carcinoma Cells
    PMID: 33835469
    Tokai J Exp Clin Med. 2021 Apr 20;46(1):7-16.

トップに戻る

2020年

英文

  • Kintaka, Y., N. Wada, S. Shioda, S. Nakamura, Y. Yamazaki, and K. Mochizuki. 2020. Excessive folic acid supplementation in pregnant mice impairs insulin secretion and induces the expression of genes associated with fatty liver in their offspring. Heliyon. 6:e03597. doi:10.1016/j.heliyon.2020.e03597.
  • Konno, T., T. Kohno, T. Okada, H. Shimada, S. Satohisa, S. Kikuchi, T. Saito, and T. Kojima. 2020. ASPP2 suppression promotes malignancy via LSR and YAP in human endometrial cancer. Histochem Cell Biol. 154:197–213. doi:10.1007/s00418-020-01876-8.
  • Kyuno, D., A. Takasawa, S. Kikuchi, I. Takemasa, M. Osanai, and T. Kojima. 2020a. Role of tight junctions in the epithelial-to-mesenchymal transition of cancer cells. Biochimica Et Biophysica Acta Biomembr. 1863:183503. doi:10.1016/j.bbamem.2020.183503.
  • Kyuno, T., D. Kyuno, T. Kohno, T. Konno, S. Kikuchi, C. Arimoto, H. Yamaguchi, M. Imamura, Y. Kimura, M. Kondoh, I. Takemasa, and T. Kojima. 2020b. Tricellular tight junction protein LSR/angulin-1 contributes to the epithelial barrier and malignancy in human pancreatic cancer cell line. Histochem Cell Biol. 153:5–16. doi:10.1007/s00418-019-01821-4.
  • Hayashi, T., T. Kubota, M. Inoue, I. Takamoto, M. Aihara, Y. Sakurai, N. Wada, T. Miki, T. Yamauchi, N. Kubota, and T. Kadowaki. 2021. Lack of brain insulin receptor substrate-1 causes growth retardation, with decreased expression of growth hormone-releasing hormone in the hypothalamus. Diabetes. db200482. doi:10.2337/db20-0482.
  • Miyakawa, M., T. Konno, T. Kohno, S. Kikuchi, H. Tanaka, and T. Kojima. 2020. Increase in Epithelial Permeability and Cell Metabolism by High Mobility Group Box 1, Inflammatory Cytokines and TPEN in Caco-2 Cells as a Novel Model of Inflammatory Bowel Disease. Int J Mol Sci. 21:8434. doi:10.3390/ijms21228434.
  • Ogasawara, Y., J. Cheng, T. Tatematsu, M. Uchida, O. Murase, S. Yoshikawa, Y. Ohsaki, and T. Fujimoto. 2020. Long-term autophagy is sustained by activation of CCTβ3 on lipid droplets. Nat Commun. 11:4480. doi:10.1038/s41467-020-18153-w.
  • Atsuo Takeda, Naoharu Takano, Hiroko Kokuba, Hirotsugu Hino, Shota Moriya, Akihisa Abe, Masaki Hiramoto, Kiyoaki Tsukahara, Keisuke Miyazawa Macrolide antibiotics enhance the antitumor effect of lansoprazole resulting in lysosomal membrane permeabilization?associated cell death
    PMID: 33173988 
    Int J Oncol. 2020 Dec;57(6):1280-1292. doi: 10.3892/ijo.2020.5138. Epub 2020 Oct 21.
  • Ayuka Yokota, Masaki Hiramoto, Hirotsugu Hino, Mayumi Tokuhisa, Masaya Miyazaki, Hiromi Kazama, Naoharu Takano, Keisuke Miyazawa Sequestosome 1 (p62) accumulation in breast cancer cells suppresses progesterone receptor expression via argonaute 2
    PMID: 32800344
    Biochem Biophys Res Commun. 2020 Oct 15;531(2):256-263. doi: 10.1016/j.bbrc.2020.07.058. Epub 2020 Aug 13.
  • Hirotsugu Hino, Noriyoshi Iriyama, Hiroko Kokuba, Hiromi Kazama, Shota Moriya, Naoharu Takano, Masaki Hiramoto, Shin Aizawa, Keisuke Miyazawa Abemaciclib induces atypical cell death in cancer cells characterized by formation of cytoplasmic vacuoles derived from lysosomes
    PMID: 32304130
    Cancer Sci. 2020 Jun;111(6):2132-2145. doi: 10.1111/cas.14419.
  • Hideki Tanaka, Hirotsugu Hino, Shota Moriya, Hiromi Kazama, Masaya Miyazaki, Naoharu Takano, Masaki Hiramoto, Kiyoaki Tsukahara, Keisuke Miyazawa  Comparison of autophagy inducibility in various tyrosine kinase inhibitors and their enhanced cytotoxicity via inhibition of autophagy in cancer cells in combined treatment with azithromycin
    PMID: 32195376
    Biochem Biophys Rep. 2020 Mar 17:22:100750. doi: 10.1016/j.bbrep.2020.100750. eCollection 2020 Jul.
  • Shinsuke Miyazawa, Shota Moriya, Hiroko Kokuba, Hirotsugu Hino, Naoharu Takano, Keisuke Miyazawa:  Vitamin K2 induces non-apoptotic cell death along with autophagosome formation in breast cancer cell lines
    PMID: 31625014
    Breast Cancer. 2020 Mar;27(2):225-235. doi: 10.1007/s12282-019-01012-y. Epub 2019 Oct 17.
     

トップに戻る

2019年

英文

  • Kakiuchi, A., T. Kohno, T. Kakuki, Y. Kaneko, T. Konno, Y. Hosaka, T. Hata, S. Kikuchi, T. Ninomiya, T. Himi, K. Takano, and T. Kojima. 2019. Rho-kinase and PKCα Inhibition Induces Primary Cilia Elongation and Alters the Behavior of Undifferentiated and Differentiated Temperature-sensitive Mouse Cochlear Cells. J Histochem Cytochem. 67:523–535. doi:10.1369/0022155419841013.
  • Konari, N., K. Nagaishi, S. Kikuchi, and M. Fujimiya. 2019. Mitochondria transfer from mesenchymal stem cells structurally and functionally repairs renal proximal tubular epithelial cells in diabetic nephropathy in vivo. Sci Rep-uk. 9:5184. doi:10.1038/s41598-019-40163-y.
  • Konno, T., T. Kohno, S. Kikuchi, H. Shimada, S. Satohisa, T. Saito, M. Kondoh, and T. Kojima. 2019a. Epithelial barrier dysfunction and cell migration induction via JNK/cofilin/actin by angubindin-1. Tissue Barriers. 8:1695475. doi:10.1080/21688370.2019.1695475.
  • Konno, T., T. Kohno, S. Kikuchi, H. Shimada, S. Satohisa, K. Takano, T. Saito, and T. Kojima. 2019b. Localization of Tricellular Tight Junction Molecule LSR at Midbody and Centrosome During Cytokinesis in Human Epithelial Cells. J Histochem Cytochem. 68:59–72. doi:10.1369/0022155419886263.
  • Murayama, Y., N. Yahagi, Y. Takeuchi, Y. Aita, Z.M. Saber, N. Wada, E. Li, X. Piao, Y. Sawada, A. Shikama, Y. Masuda, M. Nishi‐Tatsumi, M. Kubota, Y. Izumida, T. Miyamoto, M. Sekiya, T. Matsuzaka, Y. Nakagawa, Y. Sugano, H. Iwasaki, K. Kobayashi, S. Yatoh, H. Suzuki, H. Yagyu, Y. Kawakami, and H. Shimano. 2019. Glucocorticoid receptor suppresses gene expression of Rev‐erbα (Nr1d1) through interaction with the CLOCK complex. Febs Lett. 593:423–432. doi:10.1002/1873-3468.13328.
  • Shimobayashi, S.F., and Y. Ohsaki. 2019. Universal phase behaviors of intracellular lipid droplets. P Natl Acad Sci Usa. 116:25440–25445. doi:10.1073/pnas.1916248116.
  • Shioda, S., F. Takenoya, T. Hirabayashi, N. Wada, T. Seki, N. Nonaka, and T. Nakamachi. 2019. Effects of PACAP on Dry Eye Symptoms, and Possible Use for Therapeutic Application. J Mol Neurosci. 68:420–426. doi:10.1007/s12031-018-1087-1.
  • So?tysik, K., Y. Ohsaki, and T. Fujimoto. 2019a. Duo in a Mystical Realm—Nuclear Lipid Droplets and the Inner Nuclear Membrane. Contact. 2:251525641989696. doi:10.1177/2515256419896965.
  • So?tysik, K., Y. Ohsaki, T. Tatematsu, J. Cheng, and T. Fujimoto. 2019c. Nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis. Nat Commun. 10:473. doi:10.1038/s41467-019-08411-x.
  • Takenoya, F., S. Hirako, N. Wada, N. Nonaka, T. Hirabayashi, H. Kageyama, and S. Shioda. 2019. Regulation of Feeding Behavior and Energy Metabolism by Galanin-like Peptide (GALP): A Novel Strategy to Fight Against Obesity. Curr Pharm Design. 24:3926–3933. doi:10.2174/1381612824666181106111623.
  • Kohki Ota, Takashi Okuma, Alberto De Lorenzo, Ayuka Yokota, Hirotsugu Hino, 　Hiromi Kazama, Shota Moriya, Naoharu Takano, Masaki Hiramoto, Keisuke Miyazawa: Fingolimod sensitizes EGFR wild-type non-small cell lung cancer cells to lapatinib or sorafenib and induces cell cycle arrest
    PMID: 31059070
    Oncol Rep. 2019 Jul;42(1):231-242. doi: 10.3892/or.2019.7140. Epub 2019 May 2.
     

和文

  • 大﨑 雄樹. 脂肪滴の制御と疾患の関わり. 医学のあゆみ編集部編. 医学のあゆみ (特集 脂質クオリティ研究の基礎と臨床) vol.269. 東京: 医歯薬出版株式会社; 2019. pp1122-1128.
  • 大﨑 雄樹, 藤本豊士. 核内脂肪滴の形成機序と機能の解明. The Lipid編集委員会編. The Lipid (特集 生体制御にかかわる多彩なリポクオリティ?基礎から臨床まで?) vol.30. 大阪: メディカルレビュー社; 2019. pp346-351.

トップに戻る

2018年

英文

  • Hirabayashi, T., M. Yamashita, N. Wada, F. Takenoya, H. Ikeda, J. Kamei, T. Ryushi, N. Yamamoto, and S. Shioda. 2018. Analgesic effect of mineral cream containing natural spa minerals for use on the skin. Biomed Res. 39:215–222. doi:10.2220/biomedres.39.215.
  • Kikuchi, S., T. Ninomiya, T. Kohno, T. Kojima, and H. Tatsumi. 2017. Cobalt inhibits motility of axonal mitochondria and induces axonal degeneration in cultured dorsal root ganglion cells of rat. Cell Biol Toxicol. 34:93–107. doi:10.1007/s10565-017-9402-0.
  • Kimura, H., K. Arasaki, Y. Ohsaki, T. Fujimoto, T. Ohtomo, J. Yamada, and M. Tagaya. 2018. Syntaxin 17 promotes lipid droplet formation by regulating the distribution of acyl-CoA synthetase 3. J Lipid Res. 59:805–819. doi:10.1194/jlr.m081679.
  • Takir, G.G., Y. Ohsaki, K. Morotomi-Yano, K. Yano, and H. Saitoh. 2018. Linkage between lipid droplet formation and nuclear deformation in HeLa human cervical cancer cells. Biochem Bioph Res Co. 504:485–490. doi:10.1016/j.bbrc.2018.08.200.
  • Tazaki, T., K. Tabata, A. Ainai, Y. Ohara, S. Kobayashi, T. Ninomiya, Y. Orba, H. Mitomo, T. Nakano, H. Hasegawa, K. Ijiro, H. Sawa, T. Suzuki, and K. Niikura. 2018. Shape-dependent adjuvanticity of nanoparticle-conjugated RNA adjuvants for intranasal inactivated influenza vaccines. Rsc Adv. 8:16527–16536. doi:10.1039/c8ra01690a.
  • Yu Saito, Shota Moriya, Hiromi Kazama, Kazuhiro Hirasawa, Kana Miyahara, 　Hiroko Kokuba, Hirotsugu Hino, Hiroyuki Kikuchi, Naoharu Takano, Masaki Hiramoto, 　Kiyoaki Tsukahara, Keisuke Miyazawa:
    Amino acid starvation culture condition sensitizes EGFR-expressing cancer cell lines to 　gefitinib-mediated cytotoxicity by inducing atypical necroptosis
    PMID: 29484439 
    Int J Oncol. 2018 Apr;52(4):1165-1177. doi: 10.3892/ijo.2018.4282. Epub 2018 Feb 23.

和文

  • 大﨑 雄樹．細胞質および核質での脂肪滴の形成．金原一郎記念医学医療財団編. 生体の化学 (特集 生体膜のバイオロジー) vol.69. 東京: 医学書院; 2018. pp208-212.

トップに戻る

2017年

英文

  • Aktar, S., S. Takatori, T. Tsuji, M. Orii, Y. Ohsaki, J. Cheng, and T. Fujimoto. 2017. A New Electron Microscopic Method to Observe the Distribution of Phosphatidylinositol 3,4-bisphosphate. Acta Histochem Cytoc. 50:141–147. doi:10.1267/ahc.17025.
  • Coutinho, E.A., S. Okamoto, A.W. Ishikawa, S. Yokota, N. Wada, T. Hirabayashi, K. Saito, T. Sato, K. Takagi, C.-C. Wang, K. Kobayashi, Y. Ogawa, S. Shioda, Y. Yoshimura, and Y. Minokoshi. 2017. Activation of SF1 Neurons in the Ventromedial Hypothalamus by DREADD Technology Increases Insulin Sensitivity in Peripheral Tissues. Diabetes. 66:db161344. doi:10.2337/db16-1344.
  • Ishii, M., J. Kino, N. Ichinohe, N. Tanimizu, T. Ninomiya, H. Suzuki, T. Mizuguchi, K. Hirata, and T. Mitaka. 2017. Hepatocytic parental progenitor cells of rat small hepatocytes maintain self-renewal capability after long-term culture. Sci Rep-uk. 7:46177. doi:10.1038/srep46177.
  • Kaneko, Y., T. Kohno, T. Kakuki, K. Takano, N. Ogasawara, R. Miyata, S. Kikuchi, T. Konno, T. Ohkuni, R. Yajima, A. Kakiuchi, S. Yokota, T. Himi, and T. Kojima. 2017. The role of transcriptional factor p63 in regulation of epithelial barrier and ciliogenesis of human nasal epithelial cells. Sci Rep-uk. 7:10935. doi:10.1038/s41598-017-11481-w.
  • Kohno, T., S. Kikuchi, T. Ninomiya, and T. Kojima. 2017. The bicellular tensile force sorts the localization of LSRs in bicellular and tricellular junctions. Ann Ny Acad Sci. 1397:185–194. doi:10.1111/nyas.13362.
  • Ohsaki, Y., K. So?tysik, and T. Fujimoto. 2017. Organelle Contact Sites. Adv Exp Med Biol. 997:111–120. doi:10.1007/978-981-10-4567-7_8.
  • Sasaki, H., M. Yamauchi, T. Ninomiya, H. Tatsumi, and M. Yamakage. 2017. Possible utility of contrast-enhanced ultrasonography for detecting spread of local anesthetic in nerve block. J Anesth. 31:365–373. doi:10.1007/s00540-017-2347-x.
  • Sawada, Y., Y. Izumida, Y. Takeuchi, Y. Aita, N. Wada, E. Li, Y. Murayama, X. Piao, A. Shikama, Y. Masuda, M. Nishi-Tatsumi, M. Kubota, M. Sekiya, T. Matsuzaka, Y. Nakagawa, Y. Sugano, H. Iwasaki, K. Kobayashi, S. Yatoh, H. Suzuki, H. Yagyu, Y. Kawakami, T. Kadowaki, H. Shimano, and N. Yahagi. 2017. Effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on weight loss is partly mediated by liver-brain-adipose neurocircuitry. Biochem Bioph Res Co. 493:40–45. doi:10.1016/j.bbrc.2017.09.081.
  • Takano, K., T. Kakuki, Y. Kaneko, T. Kohno, S. Kikuchi, T. Himi, and T. Kojima. 2017. Histone deacetylase inhibition prevents cell death induced by loss of tricellular tight junction proteins in temperature-sensitive mouse cochlear cells. Plos One. 12:e0182291. doi:10.1371/journal.pone.0182291.
  •  Noriyoshi Iriyama*, Hirotsugu Hino*, Shota Moriya, Masaki Hiramoto, Yoshihiro Hatta, Masami Takei, Keisuke Miyazawa (*contributed equally):　The cyclin-dependent kinase 4/6 inhibitor, abemaciclib, exerts dose-dependent cytostatic 　and cytocidal effects and induces autophagy in multiple myeloma cells
    PMID: 28918692
    Leuk Lymphoma. 2018 Jun;59(6):1439-1450. doi: 10.1080/10428194.2017.1376741. Epub 2017 Sep 18.

和文

  • 藤本 豊士, 大﨑 雄樹，辻 琢磨. 電子顕微鏡による脂肪滴と膜脂質の探索. Proc Clin Electron Microsc 2017;35. 東北臨床超微細形態懇話会.
  • 泉田 欣彦, 和田 亘弘. 【第5回】 近親婚が同率で行われるコホートにおけるヒト?ノックアウトと表現型解析. The Lipids. メディカルレビュー社. 28巻4号: 2017年. pp.398-399.
  • 泉田 欣彦, 和田 亘弘, 升田 紫, 門脇 孝. 肝分泌型代謝制御因子阻害作用による肥満治療に関する特許 (WO2017-195901)
  • 塩田 清二, 和田 亘弘, 平子 哲史. 鯨肉抽出物による認知症予防改善に関する特許 (特許公開番号2016-102068 / in Japan)

トップに戻る

2016年

英文

  • Ichikawa, R., K. Hashimoto, T. Miyazaki, M. Uchigashima, M. Yamasaki, A. Aiba, M. Kano, and M. Watanabe. 2016a. Territories of heterologous inputs onto Purkinje cell dendrites are segregated by mGluR1-dependent parallel fiber synapse elimination. P Natl Acad Sci Usa. 113:2282–7. doi:10.1073/pnas.1511513113.
  • Ichikawa, R., K. Sakimura, and M. Watanabe. 2016b. GluD2 Endows Parallel Fiber-Purkinje Cell Synapses with a High Regenerative Capacity. J Neurosci Official J Soc Neurosci. 36:4846–58. doi:10.1523/jneurosci.0161-16.2016.
  • Kageyama, H., K. Shiba, S. Hirako, N. Wada, S. Yamanaka, Y. Nogi, F. Takenoya, N. Nonaka, T. Hirano, S. Inoue, and S. Shioda. 2016. Anti-obesity effect of intranasal administration of galanin-like peptide (GALP) in obese mice. Sci Rep-uk. 6:28200. doi:10.1038/srep28200.
  • Kakuki, T., Y. Kaneko, K. Takano, T. Ninomiya, T. Kohno, T. Kojima, and T. Himi. 2016. Behavior of Primary Cilia and Tricellular Tight Junction Proteins during Differentiation in Temperature-Sensitive Mouse Cochlear Precursor Hair Cells. Adv Oto-rhino-laryng. 77:27–32. doi:10.1159/000441867.
  • Hirako, S., N. Wada, H. Kageyama, F. Takenoya, H. Kim, Y. Iizuka, A. Matsumoto, M. Okabe, and S. Shioda. 2017. Effect of intranasal administration of galanin-like peptide (GALP) on body weight and hepatic lipids accumulation in mice with diet-induced obesity. Curr Pharm Design. 23. doi:10.2174/1381612823666170321095950.
  • Hirako, S., Y. Wakayama, H. Kim, Y. Iizuka, A. Matsumoto, N. Wada, A. Kimura, M. Okabe, J. Sakagami, M. Suzuki, F. Takenoya, and S. Shioda. 2016c. The relationship between aquaglyceroporin expression and development of fatty liver in diet-induced obesity and ob/ob mice. Obes Res Clin Pract. 10:710–718. doi:10.1016/j.orcp.2015.12.001.
  • Nambara, K., K. Niikura, H. Mitomo, T. Ninomiya, C. Takeuchi, J. Wei, Y. Matsuo, and K. Ijiro. 2016. Reverse Size Dependences of the Cellular Uptake of Triangular and Spherical Gold Nanoparticles. Langmuir Acs J Surfaces Colloids.
  • Ohsaki, Y., T. Kawai, Y. Yoshikawa, J. Cheng, E. Jokitalo, and T. Fujimoto. 2016. PML isoform II plays a critical role in nuclear lipid droplet formation. J Cell Biology. 212:29–38. doi:10.1083/jcb.201507122.
  • Shioda, S., F. Takenoya, N. Wada, T. Hirabayashi, T. Seki, and T. Nakamachi. 2016. Pleiotropic and retinoprotective functions of PACAP. Anat Sci Int. 91:313–324. doi:10.1007/s12565-016-0351-0.
  • Wada, N., S. Yamanaka, J. Shibato, R. Rakwal, S. Hirako, Y. Iizuka, H. Kim, A. Matsumoto, A. Kimura, F. Takenoya, G. Yasunaga, and S. Shioda. 2016. Behavioral and omics analyses study on potential involvement of dipeptide balenine through supplementation in diet of senescence-accelerated mouse prone 8. Genom Data. 10:38–50. doi:10.1016/j.gdata.2016.09.004.
  • Wada, N. 2016a. Handbook of Hormones. Part Peptides Proteins Vertebrates Sect 3gastrointestinal Hormones Sect 3 Gastrointest Hormones. 203-e24-2. doi:10.1016/b978-0-12-801028-0.00024-6.
  • Wada, N. 2016b. Handbook of Hormones. Part Peptides Proteins Vertebrates Sect 5other Peripher Hormones Sect 5 Other Peripher Hormones. 306-e34A-4. doi:10.1016/b978-0-12-801028-0.00191-4.
  • Wada, N. 2016c. Handbook of Hormones. Part Peptides Proteins Vertebrates Sect 3gastrointestinal Hormones Sect 3 Gastrointest Hormones. 209–210. doi:10.1016/b978-0-12-801028-0.00164-1.
  • Satoru Mochida, Scott Rata, Hirotsugu Hino, Takeharu Nagai, Béla Novák:Two Bistable Switches Govern M Phase Entry.
    PMID: 27889260
    Curr Biol. 2016 Dec 19;26(24):3361-3367. doi: 10.1016/j.cub.2016.10.022. Epub 2016 Nov 23.

トップに戻る

2015年

英文

  • Chiang, H., N. Ohno, Y.-L. Hsieh, D.J. Mahad, S. Kikuchi, H. Komuro, S.-T. Hsieh, and B.D. Trapp. 2015. Mitochondrial fission augments capsaicin-induced axonal degeneration. Acta Neuropathol. 129:81–96. doi:10.1007/s00401-014-1354-3.
  • Kohno, T., T. Ninomiya, S. Kikuchi, T. Konno, and T. Kojima. 2015. Staurosporine Induces Formation of Two Types of Extra-Long Cell Protrusions: Actin-Based Filaments and Microtubule-Based Shafts. Mol Pharmacol. 87:815–824. doi:10.1124/mol.114.096982.
  • Konno, T., T. Ninomiya, T. Kohno, S. Kikuchi, N. Sawada, and T. Kojima. 2015. c-Jun N-terminal kinase inhibitor SP600125 enhances barrier function and elongation of human pancreatic cancer cell line HPAC in a Ca-switch model. Histochem Cell Biol. 143:471–479. doi:10.1007/s00418-014-1300-4.
  • Takenoya, F., S. Hirako, N. Wada, N. Yamamoto, T. Wada, T. Ryushi, H. Kageyama, and S. Shioda. 2015a. Interactive Effect of Galanin-like Peptide (GALP) And Spontaneous Exercise On Energy Metabolism In Mouse. Medicine Sci Sports Exerc. 47:72. doi:10.1249/01.mss.0000465990.43779.99.
  • Takenoya, F., L. Wang, H. Kageyama, S. Hirako, N. Wada, H. Hashimoto, Y. Ueta, J. Sakagami, N. Nonaka, and S. Shioda. 2015b. Neuropeptide W-Induced Hypophagia is Mediated Through Corticotropin-Releasing Hormone-Containing Neurons. J Mol Neurosci. 56:789–798. doi:10.1007/s12031-015-0501-1.
  • Watanabe, J., M. Matsumoto, H. Kageyama, N. Murai, S. Sasaki, S. Hirako, N. Wada, S. Arata, and S. Shioda. 2015. Ghrelin suppresses proliferation of fetal neural progenitor cells, and induces their differentiation into neurons. Peptides. 69:40–46. doi:10.1016/j.peptides.2015.03.014.
  • Hirotsugu Hino, Kaori Takaki, Satoru Mochida:Inhibitor-1 and -2 of PP2A have preference between PP2A complexes.
    PMID: 26449453
    Biochem Biophys Res Commun. 2015 Nov 13;467(2):297-302. doi: 10.1016/j.bbrc.2015.09.168. Epub 2015 Oct 9.

トップに戻る

2014年

英文

  • Ohsaki, Y., M. Suzuki, and T. Fujimoto. 2014. Open Questions in Lipid Droplet Biology. Chem Biol. 21:86–96. doi:10.1016/j.chembiol.2013.08.009.
  • Satoshi, H., T. Fumiko, K. Haruaki, W. Nobuhiro, O. Mai, and S. Seiji. 2014. Galanin-like Peptide Ameliorates Obesity by Control of Food Intake and Energy Metabolism. Pharm Anal Acta. 05. doi:10.4172/2153-2435.1000297.
  • Yamamura, T., Y. Ohsaki, M. Suzuki, Y. Shinohara, T. Tatematsu, J. Cheng, M. Okada, N. Ohmiya, Y. Hirooka, H. Goto, and T. Fujimoto. 2014. Inhibition of Niemann-Pick-type C1-like1 by ezetimibe activates autophagy in human hepatocytes and reduces mutant α1-antitrypsin Z deposition. Hepatology Baltim Md. 59:1591–9. doi:10.1002/hep.26930.
  • Wada N., S. Hirako, F. Takenoya, H. Kageyama, M. Okabe, and S. Shioda. 2014. Leptin and its receptors. J Chem Neuroanat. 61:191–199. doi:10.1016/j.jchemneu.2014.09.002.

和文

  • 辰巳 治之, 溝口 照悟, 新見 隆彦, 太田 秀造, 二宮 孝文, 市川 量一, 菊池 真： 新しい概念としての「情報」と「情報薬」, 電子情報通信学会誌, 97: 695-701, 2014

トップに戻る

2013年

英文

  • Fujimoto, T., Y. Ohsaki, M. Suzuki, and J. Cheng. 2013. Chapter 13 Imaging Lipid Droplets by Electron Microscopy. Methods Cell Biol. 116:227–251. doi:10.1016/b978-0-12-408051-5.00012-7.
  • Ohsaki, Y., J. Cheng, K. Yamairi, X. Pan, M.M. Hussain, and T. Fujimoto. 2013. Inhibition of ADP-ribosylation suppresses aberrant accumulation of lipidated apolipoprotein B in the endoplasmic reticulum. Febs Lett. 587:3696–3702. doi:10.1016/j.febslet.2013.09.036.

トップに戻る

2012年

英文

  • Hölttä-Vuori, M., V.T. Salo, Y. Ohsaki, M.L. Suster, and E. Ikonen. 2012. Alleviation of seipinopathy-related ER stress by triglyceride storage. Hum Mol Genet. 22:1157–66. doi:10.1093/hmg/dds523.
  • Kageyama, H., F. Takenoya, S. Hirako, N. Wada, Y. Kintaka, S. Inoue, E. Ota, T. Ogawa, and S. Shioda. 2012. Neuronal circuits involving neuropeptide Y in hypothalamic arcuate nucleus-mediated feeding regulation. Neuropeptides. 46:285–289. doi:10.1016/j.npep.2012.09.007.
  • Nissilä, E., Y. Ohsaki, M. Weber-Boyvat, J. Perttilä, E. Ikonen, and V.M. Olkkonen. 2012. ORP10, a cholesterol binding protein associated with microtubules, regulates apolipoprotein B-100 secretion. Biochimica Et Biophysica Acta Bba - Mol Cell Biology Lipids. 1821:1472–1484. doi:10.1016/j.bbalip.2012.08.004.
  • Suzuki, M., Y. Ohsaki, T. Tatematsu, Y. Shinohara, T. Maeda, J. Cheng, and T. Fujimoto. 2012a. Translation Inhibitors Induce Formation of Cholesterol Ester-Rich Lipid Droplets. Plos One. 7:e42379. doi:10.1371/journal.pone.0042379.
  • Suzuki, M., T. Otsuka, Y. Ohsaki, J. Cheng, T. Taniguchi, H. Hashimoto, H. Taniguchi, and T. Fujimoto. 2012b. Derlin-1 and UBXD8 are engaged in dislocation and degradation of lipidated ApoB-100 at lipid droplets. Mol Biol Cell. 23:800–10. doi:10.1091/mbc.e11-11-0950.
  • Takenoya, F., H. Kageyama, S. Hirako, E. Ota, N. Wada, T. Ryushi, and S. Shioda. 2012. Neuropeptide W. Front Endocrinol. 3:171. doi:10.3389/fendo.2012.00171.
  • Hirotsugu Hino, Kana Arimoto, Michio Yazawa, Yota Murakami, Akiko Nakatomi:Ran and Calcineurin Can Participate Collaboratively in the Regulation of Spermatogenesis　in Scallop.Mar Biotechnol (NY). 2012 Aug;14(4):479-90. doi: 10.1007/s10126-011-9429-9. Epub 2012 Jan 15.

和文

  • 市川 量一, 山崎 美和子, 宮崎 大輔, 今野 幸太郎, 橋本 浩一, 辰巳 治之, 井上 芳郎, 狩野 正伸, 渡辺 雅彦. 発達期小脳プルキンエ細胞でみられる細胞体シナプスの入力線維のスイッチング－登上線維から籠細胞線維へ. 北海道医学雑誌、87: 73-74, 2012

トップに戻る

2011年

英文

  • Ichikawa, R., M. Yamasaki, T. Miyazaki, K. Konno, K. Hashimoto, H. Tatsumi, Y. Inoue, M. Kano, and M. Watanabe. 2011a. Developmental switching of perisomatic innervation from climbing fibers to basket cell fibers in cerebellar Purkinje cells. J Neurosci Official J Soc Neurosci. 31:16916–27. doi:10.1523/jneurosci.2396-11.2011.
  • Jansen, M., Y. Ohsaki, L.R. Rega, R. Bittman, V.M. Olkkonen, and E. Ikonen. 2010. Role of ORPs in Sterol Transport from Plasma Membrane to ER and Lipid Droplets in Mammalian Cells. Traffic. 12:218–231. doi:10.1111/j.1600-0854.2010.01142.x.
  • Suzuki, M., Y. Shinohara, Y. Ohsaki, and T. Fujimoto. 2011. Lipid droplets: size matters. J Electron Microsc. 60 Suppl 1:S101-16. doi:10.1093/jmicro/dfr016.
  • Salo, V.T., Y. Ohsaki, and E. Ikonen. 2011. Lipid droplet biogenesis. Curr Opin Lipidol. 22:505–506. doi:10.1097/mol.0b013e32834d1729.
  • Vihervaara, T., M. Jansen, R.-L. Uronen, Y. Ohsaki, E. Ikonen, and V.M. Olkkonen. 2011. Cytoplasmic oxysterol-binding proteins: sterol sensors or transporters? Chem Phys Lipids. 164:443–450. doi:10.1016/j.chemphyslip.2011.03.002.

和文

  • 辰巳 治之, 新見 隆彦, 太田 秀造, 溝口 照悟, 菊池 真, 市川 量一, 二宮 孝文, 中村 正弘，健康増進への新しい展開：医学と情報科学の融合:戦略的防衛医療構想：「情報薬」による超予防医療，バイオメカニクス学会誌，35: 24-30, 2011

トップに戻る

2010年

英文

  • Kikuchi, S., T. Ninomiya, T. Kawamata, N. Ogasawara, T. Kojima, N. Tachi, and H. Tatsumi. 2010a. The acid-sensing ion channel 2 (ASIC2) of ciliated cells in the developing rat nasal septum. Arch Histol Cytol. 73:81–89. doi:10.1679/aohc.73.81.
  • Kikuchi, S., T. Ninomiya, H. Tatsumi, N. Sawada, and T. Kojima. 2010b. Tricellulin Is Expressed in Autotypic Tight Junctions of Peripheral Myelinating Schwann Cells. J Histochem Cytochem. 58:1067–1073. doi:10.1369/jhc.2010.956326.
  • Hishiki, T., Y. Shimizu, R. Tobita, K. Sugiyama, K. Ogawa, K. Funami, Y. Ohsaki, T. Fujimoto, H. Takaku, T. Wakita, T.F. Baumert, Y. Miyanari, and K. Shimotohno. 2010. Infectivity of hepatitis C virus is influenced by association with apolipoprotein E isoforms. J Virol. 84:12048–57. doi:10.1128/jvi.01063-10.
  • Ohsaki, Y., Y. Shinohara, M. Suzuki, and T. Fujimoto. 2010a. A pitfall in using BODIPY dyes to label lipid droplets for fluorescence microscopy. Histochem Cell Biol. 133:477–480. doi:10.1007/s00418-010-0678-x.
  • Ohsaki, Y., M. Suzuki, Y. Shinohara, and T. Fujimoto. 2010b. Lysosomal accumulation of mTOR is enhanced by rapamycin. Histochem Cell Biol. 134:537–544. doi:10.1007/s00418-010-0759-x.
  • Shimizu, Y., T. Hishiki, K. Sugiyama, K. Ogawa, K. Funami, A. Kato, Y. Ohsaki, T. Fujimoto, H. Takaku, and K. Shimotohno. 2010. Lipoprotein lipase and hepatic triglyceride lipase reduce the infectivity of hepatitis C virus (HCV) through their catalytic activities on HCV-associated lipoproteins. Virology. 407:152–159. doi:10.1016/j.virol.2010.08.011.

和文

  • 篠原 友樹，大﨑 雄樹，鈴木 倫毅，藤本 豊士．脂肪滴とオートファジー．顕微鏡 (日本顕微鏡学会) 2010;45:87-90.
  • 大﨑 雄樹, 篠原 友樹, 鈴木 倫毅, 藤本 豊士. 脂質?脂肪滴の光顕?電顕検出法. 日本組織細胞化学会編. 組織細胞化学2010. 京都: 日本組織細胞化学会; 2010. 39-45.

トップに戻る

2009年

英文

  • Cheng, J., A. Fujita, Y. Ohsaki, M. Suzuki, Y. Shinohara, and T. Fujimoto. 2009. Quantitative electron microscopy shows uniform incorporation of triglycerides into existing lipid droplets. Histochem Cell Biol. 132:281–91. doi:10.1007/s00418-009-0615-z.
  • Hashimoto, K., R. ichikawa, K. Kitamura, M. Watanabe, and M. Kano. 2009. Translocation of a “winner” climbing fiber to the Purkinje cell dendrite and subsequent elimination of “losers” from the soma in developing cerebellum. Neuron. 63:106–18. doi:10.1016/j.neuron.2009.06.008.
  • Ohsaki, Y., J. Cheng, M. Suzuki, Y. Shinohara, A. Fujita, and T. Fujimoto. 2009. Biogenesis of cytoplasmic lipid droplets: From the lipid ester globule in the membrane to the visible structure. Biochimica Et Biophysica Acta Bba - Mol Cell Biology Lipids. 1791:399–407. doi:10.1016/j.bbalip.2008.10.002.

和文

  • 藤田 秋一, 大﨑 雄樹, 藤本 豊士. 脂質を観察する方法. 日本組織細胞化学会編 組織細胞化学2009. 京都: 日本組織細胞化学会; 2009. pp35-43.
  • 市川量一、岩村広太、菊池真、新見隆彦、二宮孝文、辰巳治之. シナプス構築の形成機構 -小脳プルキンエ細胞を中心に-. 札幌医学雑誌. 77: 1-6, 2009
  • 辰巳治之、明石浩史、新見隆彦、中村正弘、高橋正昇、太田秀造、二宮孝文、市川量一、菊池真、高塚伸太朗、戸倉一、穴水弘光：札幌地区:次世代ホームヘルスケアーシステム:戦略的防衛医療構想の実現に向けて，ヘルスケアとバイオ医療のための先端デバイス機器、バイオテクノロジーシリーズ（三林浩二 編），シーエムシー出版，p349-368, 2009

トップに戻る

2008年

英文

  • Fujimoto, T., Y. Ohsaki, J. Cheng, M. Suzuki, and Y. Shinohara. 2008a. Lipid droplets: a classic organelle with new outfits. Histochem Cell Biol. 130:263–279. doi:10.1007/s00418-008-0449-0.
  • Kikuchi, S., N. Kozuka, E. Uchida, T. Ninomiya, H. Tatsumi, H. Takeda, and N. Tachi. 2008a. The Change of Grip Strength in a Patient with Congenital Myotonic Dystrophy Over a 4-year Period. J Jpn Phys Ther Assoc. 11:23–27. doi:10.1298/jjpta.11.23.
  • Kikuchi, S., T. Ninomiya, T. Kawamata, and H. Tatsumi. 2008b. Expression of ASIC2 in ciliated cells and stereociliated cells. Cell Tissue Res. 333:217–224. doi:10.1007/s00441-008-0635-3.
  • Kurahashi, M., Y. Niwa, J. Cheng, Y. Ohsaki, A. Fujita, H. Goto, T. Fujimoto, S. Torihashi. 2008. Platelet-derived growth factor signals plya critical roles in differentiation of longitudinal smooth muscle cells in mouse embryonic gut. Neurogastroenterol Motil. 20:521-531. doi:10.1111/j.1365-2982.2007.01055.x
  • Ohsaki, Y., J. Cheng, M. Suzuki, A. Fujita, and T. Fujimoto. 2008. Lipid droplets are arrested in the ER membrane by tight binding of lipidated apolipoprotein B-100. J Cell Sci. 121:2415–2422. doi:10.1242/jcs.025452.
  • Urahama, Y., Y. Ohsaki, Y. Fujita, S. Maruyama, Y. Yuzawa, S. Matsuo, and T. Fujimoto. 2008. Lipid Droplet-Associated Proteins Protect Renal Tubular Cells from Fatty Acid-Induced Apoptosis. Am J Pathology. 173:1286–1294. doi:10.2353/ajpath.2008.080137.
  • Kurahashi M, Niwa Y, Cheng J, Ohsaki Y, Fujita A, Goto H, Fujimoto T, Torihashi S. Platelet-derived growth factor signals play critical roles in differentiation of longitudinal smooth muscle cells in mouse embryonic gut. Neurogastroenterol Motil 2008;20:521-531.

和文

  • 藤本 豊士, 大﨑 雄樹, 鈴木 倫毅. 脂肪滴形成のメカニズム. 膜 MEMBRANE 2008;33:17-23.
  • 市川 量一, 二宮 孝文, 辰巳 治之, 渡辺 雅彦. 小脳プルキンエ細胞とシナプス構築. 顕微鏡. 43: 296-299, 2008

トップに戻る

2007年

英文

  • Ninomiya, T., S. Kikuchi, R. ichikawa, N. Kozuka, N. Tachi, and H. Tatsumi. 2007. The appearance of aprataxin in rat cultured neuron and glia. Neurosci Res. 58:S139. doi:10.1016/j.neures.2007.06.1383.
  • Suzuki, M., Y. Sugimoto, Y. Ohsaki, M. Ueno, S. Kato, Y. Kitamura, H. Hosokawa, J.P. Davies, Y.A. Ioannou, M.T. Vanier, K. Ohno, and H. Ninomiya. 2007. Endosomal accumulation of Toll-like receptor 4 causes constitutive secretion of cytokines and activation of signal transducers and activators of transcription in Niemann-Pick disease type C (NPC) fibroblasts: a potential basis for glial cell activation in the NPC brain. J Neurosci Official J Soc Neurosci. 27:1879–91.
  • Tsuiki, E., A. Fujita, Y. Ohsaki, J. Cheng, T. Irie, K. Yoshikawa, H. Senoo, K. Mishima, T. Kitaoka, and T. Fujimoto. 2007. All- trans -Retinol Generated by Rhodopsin Photobleaching Induces Rapid Recruitment of TIP47 to Lipid Droplets in the Retinal Pigment Epithelium. Investigative Opthalmology Vis Sci. 48:2858. doi:10.1167/iovs.06-0768.

和文

  • 辰巳 治之, 新見 隆彦, 中村 正弘, 太田 秀造, 菊池 真, 市川 量一, 二宮 孝文, 明石 浩史, 石田 朗， 「情報薬」による戦略的防衛医療構想-生活習慣病への新しいアプローチ-, 臨床スポーツ医学, 24: 109-118, 2007

トップに戻る

2006年

英文

  • Cheng, J., Y. Ohsaki, K. Tauchi-Sato, A. Fujita, and T. Fujimoto. 2006. Cholesterol depletion induces autophagy. Biochem Bioph Res Co. 351:246–252. doi:10.1016/j.bbrc.2006.10.042.
  • FUJIMOTO, T., and Y. OHSAKI. 2006. Cytoplasmic Lipid Droplets. Ann Ny Acad Sci. 1086:104–115. doi:10.1196/annals.1377.010.
  • Fujimoto, T., and Y. Ohsaki. 2006. The Proteasomal and Autophagic Pathways Converge on Lipid Droplets. Autophagy. 2:299–301. doi:10.4161/auto.2904.
  • Ohsaki, Y., T. Maeda, M. Maeda, K. Tauchi-Sato, and T. Fujimoto. 2006b. Recruitment of TIP47 to lipid droplets is controlled by the putative hydrophobic cleft. Biochem Bioph Res Co. 347:279–287. doi:10.1016/j.bbrc.2006.06.074.
  • Ohsaki, Y., J. Cheng, A. Fujita, T. Tokumoto, and T. Fujimoto. 2006a. Cytoplasmic Lipid Droplets Are Sites of Convergence of Proteasomal and Autophagic Degradation of Apolipoprotein B. Mol Biol Cell. 17:2674–2683. doi:10.1091/mbc.e05-07-0659.
  • Ohsaki, Y., Y. Sugimoto, M. Suzuki, H. Hosokawa, T. Yoshimori, J.P. Davies, Y.A. Ioannou, M.T. Vanier, K. Ohno, and H. Ninomiya. 2006c. Cholesterol depletion facilitates ubiquitylation of NPC1 and its association with SKD1/Vps4. J Cell Sci. 119:2643–2653. doi:10.1242/jcs.02993.

トップに戻る

2005年

英文

  • Ohsaki, Y., T. Maeda, and T. Fujimoto. 2005. Fixation and permeabilization protocol is critical for the immunolabeling of lipid droplet proteins. Histochem Cell Biol. 124:445–452. doi:10.1007/s00418-005-0061-5.
  • Tachi, N., S. Kikuchi, N. Kozuka, and A. Nogami. 2005. A new mutation of IGHMBP2 gene in spinal muscular atrophy with respiratory distress type 1. Pediatr Neurol. 32:288–290. doi:10.1016/j.pediatrneurol.2004.11.003.

トップに戻る

2004年

英文

  • Lin, H., Y. Sugimoto, Y. Ohsaki, H. Ninomiya, A. Oka, M. Taniguchi, H. Ida, Y. Eto, S. Ogawa, Y. Matsuzaki, M. Sawa, T. Inoue, K. Higaki, E. Nanba, K. Ohno, and Y. Suzuki. 2004. N-Octyl-β-valienamine up-regulates activity of F213I mutant β-glucosidase in cultured cells: a potential chemical chaperone therapy for Gaucher disease. Biochimica Et Biophysica Acta Bba - Mol Basis Dis. 1689:219–228. doi:10.1016/j.bbadis.2004.03.007.
  • Ohsaki, Y., Y. Sugimoto M, Suzuki, ,T. Kaidoh, Y. Shimada, Y. Ohno-Iwashita, J.P. Davies, Y.A. Ioannou, K. Ohno, and H. Ninomiya. 2004. Reduced sensitivity of Niemann-Pick C1-deficient cells to?theta-toxin (perfringolysin O): sequestration of toxin to raft-enriched membrane vesicles. Histochem Cell Biol. 121:263–272. doi:10.1007/s00418-004-0643-7.

和文

  • 藤本 豊士, 藤田 豊, 大﨑 雄樹. カベオラ, ラフトと血管. 血管医学 2004;5:455-461.
  • 辰巳 治之, 新見 隆彦, 二宮 孝文, 市川 量一, 菊池 真, 中村 正弘, 明石 浩史, 戸倉 一, 医療とIT(1)医療におけるITの可能性-戦略的防衛医療構想, 札医通信, 465: 2-5, 2004

トップに戻る

2003年

英文

  • Pipo, J.R., J.-H. Feng, T. Yamamoto, Y. Ohsaki, E. Nanba, S. Tsujino, N. Sakuragawa, F. Martiniuk, H. Ninomiya, A. Oka, and K. Ohno. 2003. New GAA mutations in japanese patients with GSDII (pompe disease). Pediatr Neurol. 29:284–287. doi:10.1016/s0887-8994(03)00267-4.
  • Shibata, T., M. Watanabe, R. ichikawa, K. Ameda, and T. Koyanagi. 2003. Transient neonatal expression of NR2B/2D subunit mRNAs of the N-methyl-D-aspartate receptor in the parasympathetic preganglionic neurons in the rat spinal cord. Brain Res Dev Brain Res. 140:263–8.

和文

  • 二宮 孝文, 市川 量一, 辰巳 治之. 培養下における後根神経節細胞の形態分化と発生段階の相関. 組織培養研究. 22: 109-116, 2003

トップに戻る

2002年

英文

  • Ichikawa, R., T. Miyazaki, M. Kano, T. Hashikawa, H. Tatsumi, K. Sakimura, M. Mishina, Y. Inoue, and M. Watanabe. 2002a. Distal extension of climbing fiber territory and multiple innervation caused by aberrant wiring to adjacent spiny branchlets in cerebellar Purkinje cells lacking glutamate receptor delta 2. J Neurosci Official J Soc Neurosci. 22:8487–503.
  • Liu, M.-Y., Y. Hattori, A. Sato, R. ichikawa, X.-H. Zhang, and I. Sakuma. 2002. Ovariectomy attenuates hyperpolarization and relaxation mediated by endothelium-derived hyperpolarizing factor in female rat mesenteric artery: a concomitant decrease in connexin-43 expression. J Cardiovasc Pharm. 40:938–48.

トップに戻る

2001年

英文

  • akamura, K., T. Manabe, M. Watanabe, T. Mamiya, R. ichikawa, Y. Kiyama, M. Sanbo, T. Yagi, Y. Inoue, T. Nabeshima, H. Mori, and M. Mishina. 2001. Enhancement of hippocampal LTP, reference memory and sensorimotor gating in mutant mice lacking a telencephalon-specific cell adhesion molecule: Enhanced brain functions in telencephalin-deficient mice. Eur J Neurosci. 13:179–189. doi:10.1046/j.0953-816x.2000.01366.x.
  • Hashimoto, K., R. ichikawa, H. Takechi, Y. Inoue, A. Aiba, K. Sakimura, M. Mishina, T. Hashikawa, A. Konnerth, M. Watanabe, and M. Kano. 2001. Roles of Glutamate Receptor δ2 Subunit (GluRδ2) and Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Climbing Fiber Synapse Elimination during Postnatal Cerebellar Development. J Neurosci. 21:9701–9712. doi:10.1523/jneurosci.21-24-09701.2001.
  • Sugimoto, Y., H. Ninomiya, Y. Ohsaki, K. Higaki, J.P. Davies, Y.A. Ioannou, and K. Ohno. 2001. Accumulation of cholera toxin and GM1 ganglioside in the early endosome of Niemann–Pick C1-deficient cells. Proc National Acad Sci. 98:12391–12396. doi:10.1073/pnas.221181998.

トップに戻る

1999年

英文

  • Sugihara, T., Y. Hattori, Y. Yamamoto, F. Qi, R. ichikawa, A. Sato, M.-Y. Liu, K. Abe, and M. Kanno. 1999. Preferential Impairment of Nitric Oxide–Mediated Endothelium-Dependent Relaxation in Human Cervical Arteries After Irradiation. Circulation. 100:635–641. doi:10.1161/01.cir.100.6.635.
  • Shibata, T., M. Watanabe, R. ichikawa, Y. Inoue, and T. Koyanagi. 1999. Different expressions of??-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid andN-methyl-D-aspartate receptor subunit mRNAs between visceromotor and somatomotor neurons of the rat lumbosacral spinal cord. J Comp Neurology. 404:172–182. doi:10.1002/(sici)1096-9861(19990208)404:2<172::aid-cne3>3.0.co;2-u.
  • Toki, S., M. Watanabe, R. ichikawa, T. Shirakawa, H. Oguchi, and Y. Inoue. 1999. Early establishment of lesion-insensitive mature barrelettes corresponding to upper lip vibrissae in developing mice. Neurosci Res. 33:9–15. doi:10.1016/s0168-0102(98)00104-7.