> Research
Associate Professor
Yoshihiko Hirohashi, M.D. Ph.D.
1. Establishment of cancer immunotherapy
Since acquired immune system recognize antigens, immunization of cancer patients using tumor-associated antigens (TAAs) will bring augmentation of anti-tumor immunity. On this point of view, ...
Associate Professor
Tomohide Tsukahara, M.D. Ph.D.
Research works in our team is focused on establishment of immunotherapy for bone and soft tissue sarcoma. We perform clinical peptide vaccination phase I trials, identify specific antigens of cancer stem-like cells/cancer-initiating cells, and develop artificial antibodies against HLA/peptide complex using antibody engineering technology...
Assistant Professor
Takayuki Kanaseki, M.D. Ph.D.
Circulating CD8+T cells specifically recognize virally infected or tumor cells expressing non-self antigens, therefore the immune surveillance targets and eliminates pathogenic cells without harming healthy host cells. The necessary hallmark of specific recognition is the generation and presentation of peptide / MHC class I complex (pMHCI) on the surface of target cells. ...
