1．基本信息：
李毅，男，副教授，博士，研究生导师。主要从事人工智能在生物学方面的计算和工程应用。
主讲《人工智能导论》、《机器学习》、《数字逻辑电路》等课程。
个人网页：https://liyigerry.github.io
招收研究生要求：请参看个人网页https://liyigerry.github.io研究生要求部分。
邮箱：liyigerry@163.com
2．教育经历：
2015.09~2018.06：云南大学，生命科学学院，生物化学与分子生物学，博士
2012.09~2015.07：云南大学，物理科学与技术学院，物理电子学，硕士
2008.09~2012.07：上海电力学院，计算机与信息学院，电子信息工程，学士
3．工作经历：
2022.01~今，万博体育3.0手机版，数学与计算机学院，副教授
2019.01~2021.12，万博体育3.0手机版，数学与计算机学院，讲师
2018.06~2018.12，万博体育3.0手机版，数学与计算机学院，未定级
4．主持科研课题：
[1] 国家自然科学基金青年项目，62003068，基于深度学习的病毒包膜蛋白抗原特征研究，2021.01至2023.12，24万元，在研，主持。
[2] 国家自然科学基金委员会，地区科学基金项目，32160113，中国西南地区大疣蛛科蜘蛛系统学研究，2022-01-01 至 2025-12-31，36万元，在研，参与。
[3] 国家自然科学基金委员会，地区科学基金项目，31960198，HIV-1抗体中和表型差异的分子机制研究，2020-01 至 2023-12，33万元，在研，参与。
[4] 国家自然科学基金委员会，重大研究计划，91631304，大规模多态信息的细胞溯祖理论和统计分析方法，2017-01 至 2019-12，275万元，已结题，参与。
5．代表性论文：
(14) Yi Li, Yu-Chen Guo, Hong-Han Cheng, Xin Zeng, Xiao-Ling Zhang, Peng Sang, Ben-Hui Chen*, and Li-Quan Yang*. Deciphering gp120 sequence variation and structural dynamics in HIV neutralization phenotype by molecular dynamics simulations and graph machine learning. 2022. Proteins: Structure, Function, and Bioinformatics. https://doi.org/10.1002/prot.26322
(13) 李毅, 李爽, 张晓玲, 曾新, 桑鹏, 杨力权*. 极端中和表型HIV包膜蛋白gp120的高温分子动力学模拟研究. 2022. 原子与分子物理学报.
(12) Qin Wang, Rong Fu, Hong-Han Cheng, Yi Li, and Shi-Yan Sui*. Analysis of the resistance of small peptides from Periplaneta americana to hydrogen peroxide-induced apoptosis in human ovarian granular cells based on RNA-seq. 2022. Gene. https://doi.org/10.1016/j.gene.2021.146120
(11) 李毅, 侯江春, 吴悦莎, 桑鹏, 杨力权*. HIV包膜糖蛋白gp120结构及其动态性的研究进展. 2020. 中国病原生物学杂志.
(10) Yi Li, Xiao-Ling Zhang, Xue Yuan, Jiang-Chun Hou, Peng Sang, and Li-Quan Yang*. Probing intrinsic dynamics and conformational transition of HIV gp120 by molecular dynamics simulation. 2020. RSC Advances. https://doi.org/10.1039/D0RA06416E (SCI, 2019IF: 3.119, 中科院JCR三区)
Correction: Probing intrinsic dynamics and conformational transition of HIV gp120 by molecular dynamics simulation. https://doi.org/10.1039/D0RA90094J
(9) Yi Li, Lei Deng, Jing Liang, Guang-Heng Dong, Yuan-Ling Xia, Yun-Xin Fu*, and Shu-Qun Liu*. Molecular Dynamics Simulations Reveal Distinct Differences in Conformational Dynamics and Thermodynamics between the Unliganded and CD4-Bound States of HIV-1 gp120. 2020. Physical Chemistry Chemical Physics. https://doi.org/10.1039/C9CP06706J (SCI, 2019IF: 3.43, 中科院JCR二区, Top期刊)
(8) Yi Li, Yu-Chen Guo, Xiao-Ling Zhang, Lei Deng, Peng Sang, Li-Quan Yang*, and Shu-Qun Liu*. CD4-Binding Obstacles in Conformational Transitions and Allosteric Communications of HIV gp120. 2020. Biochimica et Biophysica Acta (BBA)-Biomembranes. https://doi.org/10.1016/j.bbamem.2020.183217 (SCI, 2019IF: 3.411, 中科院JCR二区)
(7) Li-Quan Yang, Yi-Rui Yin, Jian-Xin Shen, Yi Li, Shu-Qun Liu*, and Peng Sang*. Insight Derived from Molecular Dynamics Simulation into Cold-Adaptation Mechanism of Trypsins 2020. Journal of Biomolecular Structure and Dynamics. https://doi.org/10.1080/07391102.2019.1635529
(6) Li-Quan Yang, Gui-Yuan Chen, Yi Li, Ruo-Peng Zhang, Shu-Qun Liu*, and Peng Sang*. Insight derived from molecular dynamics simulation into dynamics and molecular motions of cuticle-degrading serine protease Ver112. 2019. Journal of Biomolecular Structure and Dynamics. https://doi.org/10.1080/07391102.2018.1471418
(5) Yi Li, Lei Deng, Li-Quan Yang, Peng Sang*, and Shu-Qun Liu*. Effects of CD4 Binding on Conformational Dynamics, Molecular Motions, and Thermodynamics of HIV-1 gp120. 2019. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms20020260(SCI, 2019IF: 4.556, 中科院JCR二区, Top期刊)
(4) Yuan-Ling Xia, Jian-Hong Sun, Shi-Meng Ai, Yi Li, Xing Du, Peng Sang, Li-Quan Yang, Yun-Xin Fu*, and Shu-Qun Liu*. Insights into the Role of Electrostatics in Temperature Adaptation: A Comparative Study of Psychrophilic, Mesophilic, and Thermophilic Subtilisin-like Serine Proteases. 2018. RSC Advances. https://doi.org/10.1039/C8RA05845H
(3) Yi Li#, Lei Deng#, Shi-Meng Ai, Peng Sang, Jing Yang, Yuan-Lin Xia, Zhi-Bi Zhang, Yun-Xin Fu*, and Shu-Qun Liu*. Insights into the Molecular Mechanism Underlying CD4-Dependency and Neutralization Sensitivity of HIV-1: A Comparative Molecular Dynamics Study on gp120s from Isolates with Different Phenotypes. 2018. RSC Advances. https://doi.org/10.1039/C8RA00425K (SCI, 2018IF: 3.049, 中科院JCR三区)
(2) Xing Du, Peng Sang, Yuan-Ling Xia, Yi Li, Jing Liang, Shi-Meng Ai, Xing-Lai Ji, Yun-Xin Fu, and Shu-Qun Liu*. Comparative Thermal Unfolding Study of Psychrophilic and Mesophilic Subtilisin-like Serine Proteases by Molecular Dynamics Simulations. 2017. Journal of Biomolecular Structure and Dynamics. https://doi.org/10.1080/07391102.2016.1188155
(1) Xing Du#, Yi Li#, Yuan-Ling Xia, Shi-Meng Ai, Jing Liang, Peng Sang, Xing-Lai Ji, and Shu-Qun Liu*. Insights into Protein–Ligand Interactions: Mechanisms, Models, and Methods. 2016. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms17020144 (SCI, 2016IF: 3.226, 中科院JCR三区)
